Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders repr...

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Bibliographic Details
Published in:Neurotherapeutics 2016-04, Vol.13 (2), p.403-417
Main Authors: Wickwire, Emerson M., Williams, Scott G., Roth, Thomas, Capaldi, Vincent F., Jaffe, Michael, Moline, Margaret, Motamedi, Gholam K., Morgan, Gregory W., Mysliwiec, Vincent, Germain, Anne, Pazdan, Renee M., Ferziger, Reuven, Balkin, Thomas J., MacDonald, Margaret E., Macek, Thomas A., Yochelson, Michael R., Scharf, Steven M., Lettieri, Christopher J.
Format: Article
Language:English
Subjects:
Actigraphy
Animals
Biomedical and Life Sciences
Biomedicine
Brain Concussion - complications
Brain Concussion - physiopathology
Brain Concussion - therapy
Brain research
Clinical Trials as Topic
Collaboration
Concussion
Current Perspectives
Current s
Health care access
Hospitals
Humans
Medicine
Neurobiology
Neurology
Neurosciences
Neurosurgery
Polysomnography
Post traumatic stress disorder
Psychiatry
Public health
Recovery (Medical)
Sleep - physiology
Sleep disorders
Sleep Wake Disorders - diagnosis
Sleep Wake Disorders - etiology
Sleep Wake Disorders - physiopathology
Sleep Wake Disorders - therapy
Traumatic brain injury
Working groups
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Summary:Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of sleep-related therapeutic interventions for mild TBI (mTBI). First, mTBI and sleep physiology are briefly reviewed. Next, essential empirical and clinical questions and knowledge gaps are addressed. Finally, actionable recommendations are offered to guide active and efficient collaboration between academic, industry, and governmental stakeholders.
ISSN:1933-7213
1878-7479
1878-7479
DOI:10.1007/s13311-016-0429-3