2014 Guidelines of Taiwan Society of Cardiology (TSOC) for the Management of Pulmonary Arterial Hypertension

Pulmonary hypertension (PH) is a hemodynamic and pathophysiologic condition, defined as a mean pulmonary arterial pressure exceeding 25 mmHg at rest. According to the recent classifications, it is grouped into pulmonary arterial hypertension (PAH), heart-related, lung-related, thromboembolic, and mi...

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Published in:Acta Cardiologica Sinica 2014-09, Vol.30 (5), p.401-444
Main Authors: Hsu, Chih-Hsin, Ho, Wan-Jing, Huang, Wei-Chun, Chiu, Yu-Wei, Hsu, Tsu-Shiu, Kuo, Ping-Hung, Hsu, Hsao-Hsun, Chang, Jia-Kan, Cheng, Chin-Chang, Lai, Chao-Lun, Liang, Kae-Woei, Lin, Shoa-Lin, Sung, Shih-Hsien, Tsai, Wei-Chuan, Weng, Ken-Pen, Hsieh, Kai-Sheng, Yin, Wei-Hsian, Lin, Shing-Jong, Wang, Kuo-Yang
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Language:English
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Pulmonary Arterial Hypertension
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Summary:Pulmonary hypertension (PH) is a hemodynamic and pathophysiologic condition, defined as a mean pulmonary arterial pressure exceeding 25 mmHg at rest. According to the recent classifications, it is grouped into pulmonary arterial hypertension (PAH), heart-related, lung-related, thromboembolic, and miscellaneous PH. In the past two decades, tremendous advances have occurred in the field of PH. These include (1) development of clinical diagnostic algorithm and a monitoring strategy dedicated to PAH, (2) defining strong rationales for screening at-risk populations, (3) advent of pulmonary specific drugs which makes PAH manageable, (4) recognition of needs of having proper strategy of combining existing pulmonary specific drugs, and/or potential novel drugs, (5) pursuit of clinical trials with optimal surrogate endpoints and study durations, (6) recognition of critical roles of PH/right ventricular function, as well as interdependence of ventricles in different conditions, especially those with various phenotypes of heart failure, and (7) for rare diseases, putting equal importance on carefully designed observation studies, various registries, etc., besides double blind randomized studies. In addition, ongoing basic and clinical research has led to further understanding of relevant physiology, pathophysiology, epidemiology and genetics of PH/PAH. This guidelines from the working group of Pulmonary Hypertension of the Taiwan Society of Cardiology is to provide updated guidelines based on the most recent international guidelines as well as Taiwan’s domestic research on PH. The guidelines aremainly for themanagement of PAH (Group 1) ; however themajority of content can be helpful for managing other types of PH.
ISSN:1011-6842