Triterpenoid saponin flaccidoside II from Anemone flaccida triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors via the MAPK-HO-1 pathway

Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive soft tissue neoplasms that are extremely rare and are frequently associated with neurofibromatosis type 1 patients. MPNSTs are typically fatal, and there is no effective treatment so far. In our previous study, we showed that fl...

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Bibliographic Details
Published in:OncoTargets and therapy 2016, Vol.9, p.1969-1979
Main Authors: Han, Lin-Tao, Fang, Yin, Cao, Yan, Wu, Feng-Hua, Liu, E, Mo, Guo-Yan, Huang, Fang
Format: Article
Language:English
Subjects:
Alzheimer's disease
Apoptosis
Care and treatment
Cell growth
Cellular signal transduction
Chemotherapy
Development and progression
Experiments
Folk medicine
Gene expression
Genetic aspects
Health aspects
Kinases
Neoplasia
Nervous system
Nervous system tumors
Original Research
Protein kinases
Ranunculaceae
Saponins
Terpenoids
Tumors
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Summary:Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive soft tissue neoplasms that are extremely rare and are frequently associated with neurofibromatosis type 1 patients. MPNSTs are typically fatal, and there is no effective treatment so far. In our previous study, we showed that flaccidoside II, one of the triterpenoid saponins isolated from Anemone flaccida Fr. Schmidt, has antitumor potential by inducing apoptosis. In the present study, we found that flaccidoside II inhibits proliferation and facilitates apoptosis in MPNST cell lines ST88-14 and S462. Furthermore, this study provides a mechanism by which the downregulation of heme oxygenase-1 via extracellular signal-regulated kinase-1/2 and p38 mitogen-activated protein kinase pathways is involved in the apoptotic role of flaccidoside II. This study suggested the potential of flaccidoside II as a novel pharmacotherapeutic approach for MPNSTs.
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S95597