Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis

Annexins are Ca(2+)-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial role in sarcoidosis pathogenesis. The mechanism of effect in sarcoidosis granuloma cells...

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Bibliographic Details
Published in:Journal of translational medicine 2016-04, Vol.14 (92), p.89-89, Article 89
Main Authors: Mirsaeidi, Mehdi, Gidfar, Sanaz, Vu, Ann, Schraufnagel, Dean
Format: Article
Language:English
Subjects:
African Americans
Animals
Annexins - chemistry
Annexins - genetics
Annexins - metabolism
Apoptosis
Binding sites
Care and treatment
Cell cycle
Chromosomes
Complications and side effects
Development and progression
Disease
Disease Models, Animal
Gene expression
Humans
Kinases
Models, Biological
Mutation
Neutrophils
Pathogenesis
Polymorphism, Genetic
Protein Binding
Proteins
Review
Sarcoidosis
Sarcoidosis - etiology
Sarcoidosis - metabolism
Tumor proteins
Zebrafish
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Summary:Annexins are Ca(2+)-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial role in sarcoidosis pathogenesis. The mechanism of effect in sarcoidosis granuloma cells may be due to alterations in apoptosis. Immune cells with a specific mutation at protein location 230 are resistant to apoptosis and consequently have continued effects on inflammation and progression of sarcoidosis. The mechanism of action of annexin A11 may be based upon alterations in delivering calcium to two different apoptosis pathways (caspase and P53).
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-016-0843-7