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Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis
Annexins are Ca(2+)-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial role in sarcoidosis pathogenesis. The mechanism of effect in sarcoidosis granuloma cells...
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| Published in: | Journal of translational medicine 2016-04, Vol.14 (92), p.89-89, Article 89 |
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| Main Authors: | , , , |
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| cites | cdi_FETCH-LOGICAL-c494t-50e1a49b726e10ea1e80698d8745b9b8658358da9a37821ce46ecd9992805e723 |
| container_end_page | 89 |
| container_issue | 92 |
| container_start_page | 89 |
| container_title | Journal of translational medicine |
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| creator | Mirsaeidi, Mehdi Gidfar, Sanaz Vu, Ann Schraufnagel, Dean |
| description | Annexins are Ca(2+)-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial role in sarcoidosis pathogenesis. The mechanism of effect in sarcoidosis granuloma cells may be due to alterations in apoptosis. Immune cells with a specific mutation at protein location 230 are resistant to apoptosis and consequently have continued effects on inflammation and progression of sarcoidosis. The mechanism of action of annexin A11 may be based upon alterations in delivering calcium to two different apoptosis pathways (caspase and P53). |
| doi_str_mv | 10.1186/s12967-016-0843-7 |
| format | article |
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Annexin A11 is one of the oldest vertebrate annexins that has a crucial role in sarcoidosis pathogenesis. The mechanism of effect in sarcoidosis granuloma cells may be due to alterations in apoptosis. Immune cells with a specific mutation at protein location 230 are resistant to apoptosis and consequently have continued effects on inflammation and progression of sarcoidosis. 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Annexin A11 is one of the oldest vertebrate annexins that has a crucial role in sarcoidosis pathogenesis. The mechanism of effect in sarcoidosis granuloma cells may be due to alterations in apoptosis. Immune cells with a specific mutation at protein location 230 are resistant to apoptosis and consequently have continued effects on inflammation and progression of sarcoidosis. 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| identifier | ISSN: 1479-5876 |
| ispartof | Journal of translational medicine, 2016-04, Vol.14 (92), p.89-89, Article 89 |
| issn | 1479-5876 1479-5876 |
| language | eng |
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| source | Open Access: PubMed Central; Publicly Available Content (ProQuest) |
| subjects | African Americans Animals Annexins - chemistry Annexins - genetics Annexins - metabolism Apoptosis Binding sites Care and treatment Cell cycle Chromosomes Complications and side effects Development and progression Disease Disease Models, Animal Gene expression Humans Kinases Models, Biological Mutation Neutrophils Pathogenesis Polymorphism, Genetic Protein Binding Proteins Review Sarcoidosis Sarcoidosis - etiology Sarcoidosis - metabolism Tumor proteins Zebrafish |
| title | Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis |
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