Green self-assembly of zein-conjugated ZnO/Cd(OH)Cl hierarchical nanocomposites with high cytotoxicity and immune organs targeting

Inorganic nanomedicines in the fight against cancer have progressed rapidly during recent years, with the synergistic advantages of multifunctional nanosystems compared to single component. Herein, a drug-combination opinion was introduced into “nanomedicine” based on the understanding of Trojan hor...

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Bibliographic Details
Published in:Scientific reports 2016-04, Vol.6 (1), p.24387-24387, Article 24387
Main Authors: Wang, Hua-Jie, Cao, Ying, Wang, Cai-Feng, Cui, Shi-Zhong, Mi, Li-Wei, Miyazawa, Teruo
Format: Article
Language:English
Subjects:
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Anaphylaxis
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - adverse effects
Antineoplastic Agents - metabolism
Cadmium Chloride - administration & dosage
Cadmium Chloride - adverse effects
Cadmium Chloride - metabolism
Cadmium Chloride - pharmacokinetics
Cancer
Cell Line, Tumor
Cytotoxicity
Drug Delivery Systems
Hemolysis
Humanities and Social Sciences
Injection
Kidney - metabolism
Kidneys
Lipid peroxidation
Liver
Liver - metabolism
Mice, Inbred BALB C
multidisciplinary
Nanocomposites
Nanocomposites - administration & dosage
Nanocomposites - adverse effects
Nanomedicine
Nanotechnology
Peroxidation
Science
Science (multidisciplinary)
Self-assembly
Tumor cells
Zein
Zein - administration & dosage
Zein - adverse effects
Zein - metabolism
Zein - pharmacokinetics
Zinc Oxide - administration & dosage
Zinc Oxide - adverse effects
Zinc Oxide - metabolism
Zinc Oxide - pharmacokinetics
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Summary:Inorganic nanomedicines in the fight against cancer have progressed rapidly during recent years, with the synergistic advantages of multifunctional nanosystems compared to single component. Herein, a drug-combination opinion was introduced into “nanomedicine” based on the understanding of Trojan horse-anti-tumor mechanism of inorganic nano-medicines. Moreover, we reported the green and facile synthesis route of mono-dispersed and rod-like zein-conjugated ZnO/Cd(OH)Cl hierarchical nanocomposites. We found that the nanocomposites exhibited high-efficiency killing ability to tumor cells through lipid peroxidation mediated-membrane disintegration route. The safety studies in BALB/c mice didn’t detect injection anaphylaxis, hemolysis and cytotoxicity. More interestingly, the nano-composites could specially accumulate in liver and kidney, which will be helpful for targeting cure to these regional cancers.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep24387