Effects of addictive drugs on adult neural stem/progenitor cells

Neural stem/progenitor cells (NSPCs) undergo a series of developmental processes before giving rise to newborn neurons, astrocytes and oligodendrocytes in adult neurogenesis. During the past decade, the role of NSPCs has been highlighted by studies on adult neurogenesis modulated by addictive drugs....

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2016-01, Vol.73 (2), p.327-348
Main Authors: Xu, Chi, Loh, Horace H., Law, Ping-Yee
Format: Article
Language:English
Subjects:
Adult Stem Cells - cytology
Adult Stem Cells - drug effects
Adult Stem Cells - metabolism
Amphetamine - pharmacology
Analgesics, Opioid - pharmacology
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cannabinoids - pharmacology
Cell Biology
Cell growth
Cell Proliferation - drug effects
Central Nervous System Stimulants - pharmacology
Cocaine - pharmacology
Drug abuse
Drug addiction
Drugs
Ethanol - pharmacology
Experimental methods
Ganglionic Stimulants - pharmacology
Humans
Life Sciences
N-Methyl-3,4-methylenedioxyamphetamine - pharmacology
Neural Stem Cells - cytology
Neural Stem Cells - drug effects
Neural Stem Cells - metabolism
Neurogenesis
Neurogenesis - drug effects
Neurotransmitter Agents - pharmacology
Nicotine - pharmacology
Review
Stem cells
Substance-Related Disorders - metabolism
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Summary:Neural stem/progenitor cells (NSPCs) undergo a series of developmental processes before giving rise to newborn neurons, astrocytes and oligodendrocytes in adult neurogenesis. During the past decade, the role of NSPCs has been highlighted by studies on adult neurogenesis modulated by addictive drugs. It has been proven that these drugs regulate the proliferation, differentiation and survival of adult NSPCs in different manners, which results in the varying consequences of adult neurogenesis. The effects of addictive drugs on NSPCs are exerted via a variety of different mechanisms and pathways, which interact with one another and contribute to the complexity of NSPC regulation. Here, we review the effects of different addictive drugs on NSPCs, and the related experimental methods and paradigms. We also discuss the current understanding of major signaling molecules, especially the putative common mechanisms, underlying such effects. Finally, we review the future directions of research in this area.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-015-2067-z