A retrospective analysis of patient-specific factors on voriconazole clearance

Voriconazole concentrations display a large variability, which cannot completely be explained by known factors. We investigated the relationships of voriconazole concentration with patient-specific variables and concomitant medication to identify clinical factors affecting voriconazole clearance. A...

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Bibliographic Details
Published in:Journal of pharmaceutical health care and sciences 2016-04, Vol.2 (1), p.10-10, Article 10
Main Authors: Dote, Satoshi, Sawai, Maki, Nozaki, Ayumu, Naruhashi, Kazumasa, Kobayashi, Yuka, Nakanishi, Hirokazu
Format: Article
Language:English
Subjects:
Dose-response relationship (Biochemistry)
Drug metabolism
Drug therapy
Pharmaceuticals
Physiological aspects
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Summary:Voriconazole concentrations display a large variability, which cannot completely be explained by known factors. We investigated the relationships of voriconazole concentration with patient-specific variables and concomitant medication to identify clinical factors affecting voriconazole clearance. A retrospective chart review of voriconazole trough concentration, laboratory data, and concomitant medication in patients was performed. The concentration/dose ratio (C/D-ratio) was assessed as a surrogate marker of total clearance by dividing voriconazole concentration by daily dose per kg of body weight. A total of 77 samples from 63 patients were obtained. In multiple linear regression analysis, increased C-reactive protein (CRP) level (p 
ISSN:2055-0294
2055-0294
DOI:10.1186/s40780-016-0044-9