Important Role of Menarche in Development of Estrogen Receptor-Negative Breast Cancer in African American Women

Menarche is a critical time point for diverging fates of mammary cells of origin. African American women have young age at menarche, which could be associated with their high rates of estrogen receptor-negative (ER-) breast cancer. In the AMBER Consortium, using harmonized data from 4426 African Ame...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 2015-09, Vol.107 (9), p.1
Main Authors: Ambrosone, Christine B, Zirpoli, Gary, Hong, Chi-Chen, Yao, Song, Troester, Melissa A, Bandera, Elisa V, Schedin, Pepper, Bethea, Traci N, Borges, Virginia, Park, Song-Yi, Chandra, Dhyan, Rosenberg, Lynn, Kolonel, Laurence N, Olshan, Andrew F, Palmer, Julie R
Format: Article
Language:English
Subjects:
Adolescent
Adult
African Americans
African Americans - statistics & numerical data
Age Factors
Aged
Breast cancer
Breast Feeding
Breast Neoplasms - chemistry
Breast Neoplasms - epidemiology
Child
Confidence intervals
Confounding Factors (Epidemiology)
Estrogens
Female
Humans
Logistic Models
Menarche
Menopause
Menstruation
Middle Aged
Odds Ratio
Parity
Pregnancy
Receptors, Estrogen - analysis
Reproductive History
Surveys and Questionnaires
United States - epidemiology
Women
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Summary:Menarche is a critical time point for diverging fates of mammary cells of origin. African American women have young age at menarche, which could be associated with their high rates of estrogen receptor-negative (ER-) breast cancer. In the AMBER Consortium, using harmonized data from 4426 African American women with breast cancer and 17 474 controls, we used polytomous logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for ages at menarche and first live birth (FLB), and the interval between, in relation to ER+ and ER- breast cancer. All statistical tests were two-sided. Risk of ER- breast cancer was reduced with later age at menarche among both parous and nulliparous women (≥15 vs
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/djv172