Serum folate, vitamin B-12 and cognitive function in middle and older age: The HAPIEE study

Nutrient status of B vitamins, particularly folate and vitamin B-12, may be related to cognitive ageing but epidemiological evidence remains inconclusive. The aim of this study was to estimate the association of serum folate and vitamin B-12 concentrations with cognitive function in middle-aged and...

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Bibliographic Details
Published in:Experimental gerontology 2016-04, Vol.76, p.33-38
Main Authors: Horvat, Pia, Gardiner, Julian, Kubinova, Ruzena, Pajak, Andrzej, Tamosiunas, Abdonas, Schöttker, Ben, Pikhart, Hynek, Peasey, Anne, Jansen, Eugene, Bobak, Martin
Format: Article
Language:English
Subjects:
Age Factors
Aged
Ageing
Aging - blood
Aging - psychology
Biomarkers
Biomarkers - blood
Cognition
Cognitive function
Cross-Sectional Studies
Eastern Europe
Europe
Female
Folate
Folic Acid - blood
Geriatric Assessment
Humans
Linear Models
Male
Memory, Short-Term
Middle Aged
Neuropsychological Tests
Nutrition Assessment
Nutritional Status
Prospective Studies
Verbal Behavior
Vitamin B 12 - blood
Vitamin B-12
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Summary:Nutrient status of B vitamins, particularly folate and vitamin B-12, may be related to cognitive ageing but epidemiological evidence remains inconclusive. The aim of this study was to estimate the association of serum folate and vitamin B-12 concentrations with cognitive function in middle-aged and older adults from three Central and Eastern European populations. Men and women aged 45–69 at baseline participating in the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) study were recruited in Krakow (Poland), Kaunas (Lithuania) and six urban centres in the Czech Republic. Tests of immediate and delayed recall, verbal fluency and letter search were administered at baseline and repeated in 2006–2008. Serum concentrations of biomarkers at baseline were measured in a sub-sample of participants. Associations of vitamin quartiles with baseline (n=4166) and follow-up (n=2739) cognitive domain-specific z-scores were estimated using multiple linear regression. After adjusting for confounders, folate was positively associated with letter search and vitamin B-12 with word recall in cross-sectional analyses. In prospective analyses, participants in the highest quartile of folate had higher verbal fluency (p
ISSN:0531-5565
1873-6815
DOI:10.1016/j.exger.2016.01.011