Computed tomography dose optimisation in cystic fibrosis:A review

Cystic fibrosis(CF)is the most common autosomal recessive disease of the Caucasian population worldwide,with respiratory disease remaining the most relevant source of morbidity and mortality.Computed tomography(CT)is frequently used for monitoring disease complications and progression.Over the last...

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Bibliographic Details
Published in:World journal of radiology 2016-04, Vol.8 (4), p.331-341
Main Authors: Ferris, Helena, Twomey, Maria, Moloney, Fiachra, O'Neill, Siobhan B, Murphy, Kevin, O'Connor, Owen J, Maher, Michael
Format: Article
Language:English
Subjects:
Cystic
fibrosis
Dose
optimization
Computed
radiation
Kalydeco
Review
tomography
Dose
Ionising
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Summary:Cystic fibrosis(CF)is the most common autosomal recessive disease of the Caucasian population worldwide,with respiratory disease remaining the most relevant source of morbidity and mortality.Computed tomography(CT)is frequently used for monitoring disease complications and progression.Over the last fifteen years there has been a six-fold increase in the use of CT,which has lead to a growing concern in relation to cumulative radiation exposure.The challenge to the medical profession is to identify dose reduction strategies that meet acceptable image quality,but fulfil the requirements of a diagnostic quality CT.Dose-optimisation,particularly in CT,is essential as it reduces the chances of patients receiving cumulative radiation doses in excess of 100 m Sv,a dose deemed significant by the United Nations Scientific Committee on the Effects of Atomic Radiation.This review article explores the current trends in imaging in CF with particular emphasis on new developments in dose optimisation.
ISSN:1949-8470
1949-8470
DOI:10.4329/wjr.v8.i4.331