Mixed squamous cell and glandular papilloma of the lung resembling early adenocarcinoma: A case report

Abstract Introduction An extremely rare case of mixed squamous cell and glandular papilloma of the lung is reported. The correlation between the radiological and the pathological features as well as the clinical pitfall in making a diagnosis is discussed. Presentation of case An asymptomatic 68-year...

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Bibliographic Details
Published in:Annals of medicine and surgery 2016-05, Vol.7, p.61-64
Main Authors: Abe, Jiro, Ito, Shigemi, Takahashi, Satomi, Sato, Ikuro, Tanaka, Ryota, Sato, Taku, Okazaki, Toshimasa
Format: Article
Language:English
Subjects:
18F-fluorodeoxyglucose positron emission tomography
Adenocarcinoma in situ
Case Report
FDG-PET
Ground glass nodule
HPVs
human papilloma viruses
Internal Medicine
Invasive lepidic adenocarcinoma
mixed squamous cell and glandular papilloma
MSCGP
Pulmonary papilloma
standardized uptake value
Surgery
SUV
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Summary:Abstract Introduction An extremely rare case of mixed squamous cell and glandular papilloma of the lung is reported. The correlation between the radiological and the pathological features as well as the clinical pitfall in making a diagnosis is discussed. Presentation of case An asymptomatic 68-year-old female with a cigarette smoking habit presented with a small nodule in her peripheral lung. A wedge resection was performed though it failed on-site diagnosis which was instead obtained following pathological scrutiny. The postsurgical course was excellent with no recurrence of disease. Discussion A small ground glass nodule gradually enlarged and transformed to a partially solid nodule a year and a half later. This transformation falsely made us suspect an early adenocarcinoma development. Eventually, the extremely rare subtype of pulmonary papilloma, with biphasic glandular and squamous cells, had been demonstrated to obstruct the peripheral bronchiole; and the adjoining alveoli had filled with a large volume of mucus. These pathological features seemed to have constituted the inner solid portion and the marginal ground glass portion respectively in the CT images, mimicking invasive lepidic adenocarcinoma. Conclusion Both pre- and intra-operative diagnoses are difficult mainly because of the rareness of the disease, however, mixed squamous cell and glandular papilloma may be considered in case the presence of primary adenocarcinoma is not validated.
ISSN:2049-0801
2049-0801
DOI:10.1016/j.amsu.2016.03.025