Astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting tubular epithelial-mesenchymal transition in vivo and in vitro

Epithelial-mesenchymal transition (EMT) induces the progression of renal tubulointerstitial fibrosis. Astragalus membranaceus (AM) is a traditional Chinese herbal medicine that has been demonstrated to exert anti-inflammatory and anti-cancer effects, in addition to protecting and supporting the immu...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2016-05, Vol.11 (5), p.1611-1616
Main Authors: SHAN, GUANG, ZHOU, XIANG-JUN, XIA, YUE, QIAN, HUI-JUN
Format: Article
Language:English
Subjects:
Astragalus (Plants)
Astragalus membranaceus
Bioengineering
Biotechnology
Care and treatment
Cellular signal transduction
Chinese medicine
Cytokines
epithelial-mesenchymal transition
Fibroblasts
Fibrosis
Gene expression
Genetic aspects
Health aspects
Kidney diseases
Kinases
Phosphorylation
Polyclonal antibodies
Proteins
renal fibrosis
Studies
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Summary:Epithelial-mesenchymal transition (EMT) induces the progression of renal tubulointerstitial fibrosis. Astragalus membranaceus (AM) is a traditional Chinese herbal medicine that has been demonstrated to exert anti-inflammatory and anti-cancer effects, in addition to protecting and supporting the immune system. The present study investigated the effects of AM on renal fibrosis. A mouse model of unilateral ureteral obstruction (UUO) was established and treated with various concentrations of AM (100, 200 or 400 mg/kg/day). Interstitial fibrosis markedly increased in the UUO mice. AM significantly reduced the obstruction-induced upregulation of α-smooth muscle actin (α-SMA) and downregulation of E-cadherin in the kidneys of the UUO mice (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2016.3152