An Experimental Method for Measuring Mechanical Properties of Rat Pulmonary Arteries Verified With Latex

This paper describes a test method for measuring the mechanical properties of small, nonlinear membrane samples from a rat model for pulmonary hypertension. The size and nonlinearity of the pulmonary artery samples poses a challenge for developing a test method that will generate quality, reproducib...

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Bibliographic Details
Published in:Journal of research of the National Institute of Standards and Technology 2003-05, Vol.108 (3), p.183-191
Main Authors: Drexler, E S, Slifka, A J, Wright, J E, McCowan, C N, Finch, D S, Quinn, T P, McColskey, J D, Ivy, D D, Shandas, R
Format: Article
Language:English
Subjects:
Lung diseases
Measurement
Membranes (Biology)
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Summary:This paper describes a test method for measuring the mechanical properties of small, nonlinear membrane samples from a rat model for pulmonary hypertension. The size and nonlinearity of the pulmonary artery samples poses a challenge for developing a test method that will generate quality, reproducible data in the pressure range experienced by the hypertensive pulmonary artery. The experimental method described here has sufficient precision to yield a combined relative standard uncertainty of 4 %. The method is calibrated against 75 µm thick latex and the data agree well with the neo-Hookian model.
ISSN:1044-677X
2165-7254
DOI:10.6028/jres.108.018