Unanticipated role of melanin in causing carcinogenic cyclobutane pyrimidine dimers

Ultraviolet radiation (UVR) instantaneously generates cyclobutane pyrimidine dimers (CPDs). Paradoxically, we recently observed that UV enables the protective pigment melanin to create CPDs in the dark long after the exposure ends. UV-induced reactive oxygen species (ROS) oxidize melanin to create m...

Full description

Saved in:
Bibliographic Details
Published in:Molecular & cellular oncology 2016-01, Vol.3 (1), p.e1033588
Main Authors: Premi, Sanjay, Brash, Douglas E.
Format: Article
Language:English
Subjects:
Author's View
DNA damage
melanin
melanoma
models of oncogenesis
photobiology
ultraviolet radiation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ultraviolet radiation (UVR) instantaneously generates cyclobutane pyrimidine dimers (CPDs). Paradoxically, we recently observed that UV enables the protective pigment melanin to create CPDs in the dark long after the exposure ends. UV-induced reactive oxygen species (ROS) oxidize melanin to create melanin carbonyls in a high-energy quantum state. These energetic melanin carbonyls transfer their energy to DNA in the dark, creating CPDs in the absence of UVR.
ISSN:2372-3556
2372-3556
DOI:10.1080/23723556.2015.1033588