Effects of Anesthetic Agent Propofol on Postoperative Sex Hormone Levels

Abstract Introduction: Several studies have found anesthetic agents including propofol in ovarian follicular fluid. However, little is known about the effect of anesthetic agents on ovarian function. We aimed to investigate whether there were differences in the postoperative levels of sex hormones w...

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Published in:Geburtshilfe und Frauenheilkunde 2016-04, Vol.76 (4), p.408-412
Main Authors: Kim, H., Ku, S.-Y., Kim, H. C., Suh, C. S., Kim, S. H., Choi, Y. M.
Format: Article
Language:English
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Summary:Abstract Introduction: Several studies have found anesthetic agents including propofol in ovarian follicular fluid. However, little is known about the effect of anesthetic agents on ovarian function. We aimed to investigate whether there were differences in the postoperative levels of sex hormones when propofol was used as the anesthetic agent. Methods: A retrospective review was done of 80 patients who underwent ovarian surgery, with 72 infertile women serving as controls. Patients were included in the study if their serum estradiol (E2) and follicle stimulating hormone (FSH) levels were measured during their first postoperative menstrual cycle. Results: Patients were grouped according to the use or non-use of propofol as follows: propofol group (n = 39) and non-propofol group (n = 41). The control group did not undergo surgery. Postoperative E2 levels did not differ between the three groups, but FSH levels were significantly higher in the patients who had undergone surgery compared to controls (p 
ISSN:0016-5751
1438-8804
DOI:10.1055/s-0041-111571