Inflammation and nutrition in children with chronic kidney disease

Chronic inflammation and nutritional imbalance are important comorbid conditions that correlate with poor clinical outcomes in children with chronic kidney disease(CKD). Nutritional disorders such as cachexia/protein energy wasting, obesity and growth retardation negatively impact the quality of lif...

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Bibliographic Details
Published in:World journal of nephrology 2016-05, Vol.5 (3), p.274-282
Main Authors: Tu, Juan, Cheung, Wai W, Mak, Robert H
Format: Article
Language:English
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Summary:Chronic inflammation and nutritional imbalance are important comorbid conditions that correlate with poor clinical outcomes in children with chronic kidney disease(CKD). Nutritional disorders such as cachexia/protein energy wasting, obesity and growth retardation negatively impact the quality of life and disease progression in children with CKD. Inadequate nutrition has been associated with growth disturbances in children with CKD. On the other hand, over-nutrition and obesity are associated with poor outcomes in children with CKD. The exact mechanisms leading to these unfavorable conditions are not fully elucidated and are most likely multifactorial. In this review, we focus on the pathophysiology of nutrition disorders and inflammation and their impact on clinical outcomes in children with CKD.
ISSN:2220-6124
2220-6124
DOI:10.5527/wjn.v5.i3.274