Peri-infarct depolarizations during focal ischemia in the awake Spontaneously Hypertensive Rat. Minimizing anesthesia confounds in experimental stroke

Highlights • Peri-infarct depolarizations (PIDs) were recorded in awake rats during stroke. • Recovery for 2 weeks after electrode placement avoided anesthetic preconditioning. • PIDs ceased within 4 or 36 h after permanent or transient occlusions, respectively. • PID suppression by sustained anesth...

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Bibliographic Details
Published in:Neuroscience 2016-06, Vol.325, p.142-152
Main Authors: Kudo, K, Zhao, L, Nowak, T.S
Format: Article
Language:English
Subjects:
anesthetic preconditioning
Anesthetics, Inhalation - adverse effects
Animals
Brain Ischemia - physiopathology
Cerebral Cortex - drug effects
Cerebral Cortex - physiopathology
cerebral ischemia
Disease Models, Animal
Infarction, Middle Cerebral Artery - physiopathology
Isoflurane - adverse effects
Male
Neurology
peri-infarct depolarization
Rats
Rats, Inbred SHR
stroke
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Summary:Highlights • Peri-infarct depolarizations (PIDs) were recorded in awake rats during stroke. • Recovery for 2 weeks after electrode placement avoided anesthetic preconditioning. • PIDs ceased within 4 or 36 h after permanent or transient occlusions, respectively. • PID suppression by sustained anesthesia was not protective without reperfusion. • PID time course coincides with infarct progression under varied model conditions.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.03.049