Role of Msi1 and PYGO2 in esophageal squamous cell carcinoma depth of invasion

Deregulation of developmental signaling pathways such as Wnt/b-catenin and NOTCH are commonly observed in different cancers. A normal wnt pathway is essential for development and tissue homeostasis to preserve a normal balance between the differentiation and proliferation. PYGO2 is the main transcri...

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Bibliographic Details
Published in:Journal of cell communication and signaling 2016-03, Vol.10 (1), p.49-53
Main Authors: Moghbeli, Meysam, Sadrizadeh, Ali, Forghanifard, Mohammad Mahdi, Mozaffari, Hooman Mosannen, Golmakani, Ebrahim, Abbaszadegan, Mohammad Reza
Format: Article
Language:English
Subjects:
Biomedicine
Cancer stem cell
Cell Biology
Esophagus
Expressional analysis
Feedback
Gene expression
Homeostasis
Life Sciences
Metastasis
Msi1 protein
NOTCH pathway
Polymerase chain reaction
Research Article
Squamous cell carcinoma
Suppressor
Translation
Tumor
Wnt pathway
Wnt protein
β-catenin
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Summary:Deregulation of developmental signaling pathways such as Wnt/b-catenin and NOTCH are commonly observed in different cancers. A normal wnt pathway is essential for development and tissue homeostasis to preserve a normal balance between the differentiation and proliferation. PYGO2 is the main transcription factor of wnt pathway, while Msi1 is one of the wnt inhibitors. In this study we assessed the correlation between Msi1 and PYGO2 mRNA expression using Real time polymerase chain reaction in 48 esophageal squamous cell carcinoma (ESCC) patients. Although, there was not any significant correlation between the levels of Msi1 and PYGO2 mRNA expression, we observed a significant correlation between the Msi1 and PYGO2 overexpressed cases and depth of tumor invasion ( p  = 0.05). In conclusion, despite the role of these markers in tumor depth of invasion there is not any feedback between Msi1 and PYGO2 gene expression in ESCC.
ISSN:1873-9601
1873-961X
DOI:10.1007/s12079-015-0314-6