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Facial emotion processing in patients with social anxiety disorder and Williams–Beuren syndrome: an fMRI study
Background Social anxiety disorder (SAD) and Williams–Beuren syndrome (WBS) are 2 conditions with major differences in terms of genetics, development and cognitive profiles. Both conditions are associated with compromised abilities in overlapping areas, including social approach, processing of socia...
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Published in: | Journal of psychiatry & neuroscience 2016-05, Vol.41 (3), p.182-191 |
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creator | Binelli, Cynthia, PhD Muñiz, Armando, MD Martin-Santos, Rocio, MD, PhD Navines, Ricard, MD, PhD Subira, Susana, MD, PhD Blanco-Hinojo, Laura, MSc Pujol, Jesus, MD, PhD Crippa, Jose, MD, PhD Perez-Garcia, Debora, BSc Farré, Magi, MD, PhD Pérez-Jurado, Luis, MD, PhD |
description | Background Social anxiety disorder (SAD) and Williams–Beuren syndrome (WBS) are 2 conditions with major differences in terms of genetics, development and cognitive profiles. Both conditions are associated with compromised abilities in overlapping areas, including social approach, processing of social emotional cues and gaze behaviour, and to some extent they are associated with opposite behaviours in these domains. We examined common and distinct patterns of brain activation during a facial emotion processing paradigm in patients with SAD and WBS. Methods We examined patients with SAD and WBS and healthy controls matched by age and laterality using functional MRI during the processing of happy, fearful and angry faces. Results We included 20 patients with SAD and 20 with WBS as well as 20 matched controls in our study. Patients with SAD and WBS did not differ in the pattern of limbic activation. We observed differences in early visual areas of the face processing network in patients with WBS and differences in the cortical prefrontal regions involved in the top–down regulation of anxiety and in the fusiform gyrus for patients with SAD. Compared with those in the SAD and control groups, participants in the WBS group did not activate the right lateral inferior occipital cortex. In addition, compared with controls, patients with WBS hypoactivated the posterior primary visual cortex and showed significantly less deactivation in the right temporal operculum. Participants in the SAD group showed decreased prefrontal activation compared with those in the WBS and control groups. In addition, compared with controls, participants with SAD showed decreased fusiform activation. Participants with SAD and WBS also differed in the pattern of activation in the superior temporal gyrus, a region that has been linked to gaze processing. Limitations The results observed in the WBS group are limited by the IQ of the WBS sample; however, the specificity of findings suggests that the pattern of brain activation observed for WBS is more likely to reflect a neurobiological substrate rather than intellectual impairment per se. Conclusion Patients with SAD and WBS showed common and specific patterns of brain activation. Our results highlight the role of cortical regions during facial emotion processing in individuals with SAD and WBS. |
doi_str_mv | 10.1503/jpn.140384 |
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Both conditions are associated with compromised abilities in overlapping areas, including social approach, processing of social emotional cues and gaze behaviour, and to some extent they are associated with opposite behaviours in these domains. We examined common and distinct patterns of brain activation during a facial emotion processing paradigm in patients with SAD and WBS. Methods We examined patients with SAD and WBS and healthy controls matched by age and laterality using functional MRI during the processing of happy, fearful and angry faces. Results We included 20 patients with SAD and 20 with WBS as well as 20 matched controls in our study. Patients with SAD and WBS did not differ in the pattern of limbic activation. We observed differences in early visual areas of the face processing network in patients with WBS and differences in the cortical prefrontal regions involved in the top–down regulation of anxiety and in the fusiform gyrus for patients with SAD. Compared with those in the SAD and control groups, participants in the WBS group did not activate the right lateral inferior occipital cortex. In addition, compared with controls, patients with WBS hypoactivated the posterior primary visual cortex and showed significantly less deactivation in the right temporal operculum. Participants in the SAD group showed decreased prefrontal activation compared with those in the WBS and control groups. In addition, compared with controls, participants with SAD showed decreased fusiform activation. Participants with SAD and WBS also differed in the pattern of activation in the superior temporal gyrus, a region that has been linked to gaze processing. Limitations The results observed in the WBS group are limited by the IQ of the WBS sample; however, the specificity of findings suggests that the pattern of brain activation observed for WBS is more likely to reflect a neurobiological substrate rather than intellectual impairment per se. Conclusion Patients with SAD and WBS showed common and specific patterns of brain activation. Our results highlight the role of cortical regions during facial emotion processing in individuals with SAD and WBS.</description><identifier>ISSN: 1180-4882</identifier><identifier>EISSN: 1488-2434</identifier><identifier>DOI: 10.1503/jpn.140384</identifier><identifier>PMID: 26624523</identifier><identifier>CODEN: JPNEEF</identifier><language>eng</language><publisher>Canada: Joule Inc</publisher><subject>Adolescent ; Adult ; Anxiety ; Brain ; Brain - diagnostic imaging ; Brain - physiopathology ; Brain Mapping ; Emotional disorders ; Emotions - physiology ; Face ; Facial expression ; Facial Recognition - physiology ; Female ; Genetic aspects ; Health aspects ; Humans ; Magnetic Resonance Imaging ; Male ; Medical Education ; Methods ; Neurobiology ; Neuropsychological Tests ; Phobia, Social - diagnostic imaging ; Phobia, Social - physiopathology ; Phobia, Social - psychology ; Physiological aspects ; Psychiatry ; Research Paper ; Social phobia ; Studies ; Williams syndrome ; Williams Syndrome - diagnostic imaging ; Williams Syndrome - physiopathology ; Williams Syndrome - psychology ; Young Adult</subject><ispartof>Journal of psychiatry & neuroscience, 2016-05, Vol.41 (3), p.182-191</ispartof><rights>Joule Inc. or its licensors</rights><rights>COPYRIGHT 2016 Joule Inc.</rights><rights>Copyright 8872147 Canada Inc. May 2016</rights><rights>2016 Joule Inc. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-6bb452d5cd205d86c30e2284b60684bcc2134187d12ba2bf564aabbf62f29b3c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1791783321/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1791783321?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26624523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Binelli, Cynthia, PhD</creatorcontrib><creatorcontrib>Muñiz, Armando, MD</creatorcontrib><creatorcontrib>Martin-Santos, Rocio, MD, PhD</creatorcontrib><creatorcontrib>Navines, Ricard, MD, PhD</creatorcontrib><creatorcontrib>Subira, Susana, MD, PhD</creatorcontrib><creatorcontrib>Blanco-Hinojo, Laura, MSc</creatorcontrib><creatorcontrib>Pujol, Jesus, MD, PhD</creatorcontrib><creatorcontrib>Crippa, Jose, MD, PhD</creatorcontrib><creatorcontrib>Perez-Garcia, Debora, BSc</creatorcontrib><creatorcontrib>Farré, Magi, MD, PhD</creatorcontrib><creatorcontrib>Pérez-Jurado, Luis, MD, PhD</creatorcontrib><title>Facial emotion processing in patients with social anxiety disorder and Williams–Beuren syndrome: an fMRI study</title><title>Journal of psychiatry & neuroscience</title><addtitle>J Psychiatry Neurosci</addtitle><description>Background Social anxiety disorder (SAD) and Williams–Beuren syndrome (WBS) are 2 conditions with major differences in terms of genetics, development and cognitive profiles. Both conditions are associated with compromised abilities in overlapping areas, including social approach, processing of social emotional cues and gaze behaviour, and to some extent they are associated with opposite behaviours in these domains. We examined common and distinct patterns of brain activation during a facial emotion processing paradigm in patients with SAD and WBS. Methods We examined patients with SAD and WBS and healthy controls matched by age and laterality using functional MRI during the processing of happy, fearful and angry faces. Results We included 20 patients with SAD and 20 with WBS as well as 20 matched controls in our study. Patients with SAD and WBS did not differ in the pattern of limbic activation. We observed differences in early visual areas of the face processing network in patients with WBS and differences in the cortical prefrontal regions involved in the top–down regulation of anxiety and in the fusiform gyrus for patients with SAD. Compared with those in the SAD and control groups, participants in the WBS group did not activate the right lateral inferior occipital cortex. In addition, compared with controls, patients with WBS hypoactivated the posterior primary visual cortex and showed significantly less deactivation in the right temporal operculum. Participants in the SAD group showed decreased prefrontal activation compared with those in the WBS and control groups. In addition, compared with controls, participants with SAD showed decreased fusiform activation. Participants with SAD and WBS also differed in the pattern of activation in the superior temporal gyrus, a region that has been linked to gaze processing. Limitations The results observed in the WBS group are limited by the IQ of the WBS sample; however, the specificity of findings suggests that the pattern of brain activation observed for WBS is more likely to reflect a neurobiological substrate rather than intellectual impairment per se. Conclusion Patients with SAD and WBS showed common and specific patterns of brain activation. Our results highlight the role of cortical regions during facial emotion processing in individuals with SAD and WBS.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anxiety</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiopathology</subject><subject>Brain Mapping</subject><subject>Emotional disorders</subject><subject>Emotions - physiology</subject><subject>Face</subject><subject>Facial expression</subject><subject>Facial Recognition - physiology</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical Education</subject><subject>Methods</subject><subject>Neurobiology</subject><subject>Neuropsychological Tests</subject><subject>Phobia, Social - diagnostic imaging</subject><subject>Phobia, Social - physiopathology</subject><subject>Phobia, Social - psychology</subject><subject>Physiological aspects</subject><subject>Psychiatry</subject><subject>Research Paper</subject><subject>Social phobia</subject><subject>Studies</subject><subject>Williams syndrome</subject><subject>Williams Syndrome - 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diagnostic imaging</topic><topic>Brain - physiopathology</topic><topic>Brain Mapping</topic><topic>Emotional disorders</topic><topic>Emotions - physiology</topic><topic>Face</topic><topic>Facial expression</topic><topic>Facial Recognition - physiology</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical Education</topic><topic>Methods</topic><topic>Neurobiology</topic><topic>Neuropsychological Tests</topic><topic>Phobia, Social - diagnostic imaging</topic><topic>Phobia, Social - physiopathology</topic><topic>Phobia, Social - psychology</topic><topic>Physiological aspects</topic><topic>Psychiatry</topic><topic>Research Paper</topic><topic>Social phobia</topic><topic>Studies</topic><topic>Williams syndrome</topic><topic>Williams Syndrome - diagnostic imaging</topic><topic>Williams Syndrome - physiopathology</topic><topic>Williams Syndrome - psychology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Binelli, Cynthia, PhD</creatorcontrib><creatorcontrib>Muñiz, Armando, MD</creatorcontrib><creatorcontrib>Martin-Santos, Rocio, MD, PhD</creatorcontrib><creatorcontrib>Navines, Ricard, MD, PhD</creatorcontrib><creatorcontrib>Subira, Susana, MD, PhD</creatorcontrib><creatorcontrib>Blanco-Hinojo, Laura, MSc</creatorcontrib><creatorcontrib>Pujol, Jesus, MD, PhD</creatorcontrib><creatorcontrib>Crippa, Jose, MD, PhD</creatorcontrib><creatorcontrib>Perez-Garcia, Debora, BSc</creatorcontrib><creatorcontrib>Farré, Magi, MD, PhD</creatorcontrib><creatorcontrib>Pérez-Jurado, Luis, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Canadian Business & Current Affairs Database</collection><collection>Canadian Business & Current Affairs Database (Alumni Edition)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology Journals</collection><collection>ProQuest research library</collection><collection>ProQuest Science Journals</collection><collection>CBCA Reference & Current Events</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of psychiatry & neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Binelli, Cynthia, PhD</au><au>Muñiz, Armando, MD</au><au>Martin-Santos, Rocio, MD, PhD</au><au>Navines, Ricard, MD, PhD</au><au>Subira, Susana, MD, PhD</au><au>Blanco-Hinojo, Laura, MSc</au><au>Pujol, Jesus, MD, PhD</au><au>Crippa, Jose, MD, PhD</au><au>Perez-Garcia, Debora, BSc</au><au>Farré, Magi, MD, PhD</au><au>Pérez-Jurado, Luis, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Facial emotion processing in patients with social anxiety disorder and Williams–Beuren syndrome: an fMRI study</atitle><jtitle>Journal of psychiatry & neuroscience</jtitle><addtitle>J Psychiatry Neurosci</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>41</volume><issue>3</issue><spage>182</spage><epage>191</epage><pages>182-191</pages><issn>1180-4882</issn><eissn>1488-2434</eissn><coden>JPNEEF</coden><abstract>Background Social anxiety disorder (SAD) and Williams–Beuren syndrome (WBS) are 2 conditions with major differences in terms of genetics, development and cognitive profiles. Both conditions are associated with compromised abilities in overlapping areas, including social approach, processing of social emotional cues and gaze behaviour, and to some extent they are associated with opposite behaviours in these domains. We examined common and distinct patterns of brain activation during a facial emotion processing paradigm in patients with SAD and WBS. Methods We examined patients with SAD and WBS and healthy controls matched by age and laterality using functional MRI during the processing of happy, fearful and angry faces. Results We included 20 patients with SAD and 20 with WBS as well as 20 matched controls in our study. Patients with SAD and WBS did not differ in the pattern of limbic activation. We observed differences in early visual areas of the face processing network in patients with WBS and differences in the cortical prefrontal regions involved in the top–down regulation of anxiety and in the fusiform gyrus for patients with SAD. Compared with those in the SAD and control groups, participants in the WBS group did not activate the right lateral inferior occipital cortex. In addition, compared with controls, patients with WBS hypoactivated the posterior primary visual cortex and showed significantly less deactivation in the right temporal operculum. Participants in the SAD group showed decreased prefrontal activation compared with those in the WBS and control groups. In addition, compared with controls, participants with SAD showed decreased fusiform activation. Participants with SAD and WBS also differed in the pattern of activation in the superior temporal gyrus, a region that has been linked to gaze processing. Limitations The results observed in the WBS group are limited by the IQ of the WBS sample; however, the specificity of findings suggests that the pattern of brain activation observed for WBS is more likely to reflect a neurobiological substrate rather than intellectual impairment per se. Conclusion Patients with SAD and WBS showed common and specific patterns of brain activation. Our results highlight the role of cortical regions during facial emotion processing in individuals with SAD and WBS.</abstract><cop>Canada</cop><pub>Joule Inc</pub><pmid>26624523</pmid><doi>10.1503/jpn.140384</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult Anxiety Brain Brain - diagnostic imaging Brain - physiopathology Brain Mapping Emotional disorders Emotions - physiology Face Facial expression Facial Recognition - physiology Female Genetic aspects Health aspects Humans Magnetic Resonance Imaging Male Medical Education Methods Neurobiology Neuropsychological Tests Phobia, Social - diagnostic imaging Phobia, Social - physiopathology Phobia, Social - psychology Physiological aspects Psychiatry Research Paper Social phobia Studies Williams syndrome Williams Syndrome - diagnostic imaging Williams Syndrome - physiopathology Williams Syndrome - psychology Young Adult |
title | Facial emotion processing in patients with social anxiety disorder and Williams–Beuren syndrome: an fMRI study |
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