Application of Good's buffers to pH imaging using hyperpolarized 13C MRI

N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized 13 C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its 13 C chemical shift within the p...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-09, Vol.51 (74), p.14119-14122
Main Authors: Flavell, Robert R, von Morze, Cornelius, Blecha, Joseph E., Korenchan, David, Van Criekinge, Mark, Sriram, Renuka, Gordon, Jeremy, Chen, Hsin-Yu, Subramaniam, Sukumar, Bok, Robert, Wang, Zhen J., Vigneron, Daniel, Larson, Peder, Kurhanewicz, John, Wilson, David M
Format: Article
Language:English
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Summary:N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized 13 C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its 13 C chemical shift within the physiologic range.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc05348j