Application of Good's buffers to pH imaging using hyperpolarized 13C MRI

N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized 13 C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its 13 C chemical shift within the p...

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Published in:Chemical communications (Cambridge, England) England), 2015-09, Vol.51 (74), p.14119-14122
Main Authors: Flavell, Robert R, von Morze, Cornelius, Blecha, Joseph E., Korenchan, David, Van Criekinge, Mark, Sriram, Renuka, Gordon, Jeremy, Chen, Hsin-Yu, Subramaniam, Sukumar, Bok, Robert, Wang, Zhen J., Vigneron, Daniel, Larson, Peder, Kurhanewicz, John, Wilson, David M
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container_issue 74
container_start_page 14119
container_title Chemical communications (Cambridge, England)
container_volume 51
creator Flavell, Robert R
von Morze, Cornelius
Blecha, Joseph E.
Korenchan, David
Van Criekinge, Mark
Sriram, Renuka
Gordon, Jeremy
Chen, Hsin-Yu
Subramaniam, Sukumar
Bok, Robert
Wang, Zhen J.
Vigneron, Daniel
Larson, Peder
Kurhanewicz, John
Wilson, David M
description N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized 13 C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its 13 C chemical shift within the physiologic range.
doi_str_mv 10.1039/c5cc05348j
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title Application of Good's buffers to pH imaging using hyperpolarized 13C MRI
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