Cellular senescence impact on immune cell fate and function

Summary Cellular senescence occurs not only in cultured fibroblasts, but also in undifferentiated and specialized cells from various tissues of all ages, in vitro and in vivo. Here, we review recent findings on the role of cellular senescence in immune cell fate decisions in macrophage polarization,...

Full description

Saved in:
Bibliographic Details
Published in:Aging cell 2016-06, Vol.15 (3), p.400-406
Main Authors: Vicente, Rita, Mausset‐Bonnefont, Anne‐Laure, Jorgensen, Christian, Louis‐Plence, Pascale, Brondello, Jean‐Marc
Format: Article
Language:English
Subjects:
Cell Lineage
Cellular Senescence
chronic and autoimmune diseases
Homeostasis - immunology
Humans
immune cells
Immunity
Life Sciences
Lymphocytes
Lymphocytes - cytology
Macrophages
Review
Reviews
tissue homeostasis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Cellular senescence occurs not only in cultured fibroblasts, but also in undifferentiated and specialized cells from various tissues of all ages, in vitro and in vivo. Here, we review recent findings on the role of cellular senescence in immune cell fate decisions in macrophage polarization, natural killer cell phenotype, and following T‐lymphocyte activation. We also introduce the involvement of the onset of cellular senescence in some immune responses including T‐helper lymphocyte‐dependent tissue homeostatic functions and T‐regulatory cell‐dependent suppressive mechanisms. Altogether, these data propose that cellular senescence plays a wide‐reaching role as a homeostatic orchestrator.
ISSN:1474-9718
1474-9726
1474-9728
DOI:10.1111/acel.12455