Coronary atherosclerosis burden is not advanced in patients with β-thalassemia despite premature extracardiac atherosclerosis： a coronary artery calcium score and carotid intima-media thickness study

Background Thalassemic patients demonstrate an increased rate of extracardiae vascular complications and increased carotid wall intima-media thickness （cIMT）, but very low prevalence of coronary artery disease （CAD）. We investigated the atheroma burden by assessing the coronary artery calcium （CAC）...

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Published in:Journal of geriatric cardiology : JGC 2016-02, Vol.13 (2), p.158-162
Main Authors: Hahalis, George, Zacharioglou, Evangelia, Xanthopoulou, Ioanna, Koniari, Ioanna, Kalogeropoulou, Chistina, Tsota, Irene, Rigopoulou, Aspasia, Diamantopoulos, Athanasios, Gkizas, Vasilios, Davlouros, Periklis, Akinosoglou, Karolina, Leopoulou, Marianna, Gogos, Charalampos, Alexopoulos, Dimitrios
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Language:English
Subjects:
冠状动脉粥样硬化
地中海贫血
患者
膜厚度
计算机断层扫描
评分
钙化
颈动脉
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container_issue 2
container_start_page 158
container_title Journal of geriatric cardiology : JGC
container_volume 13
creator Hahalis, George
Zacharioglou, Evangelia
Xanthopoulou, Ioanna
Koniari, Ioanna
Kalogeropoulou, Chistina
Tsota, Irene
Rigopoulou, Aspasia
Diamantopoulos, Athanasios
Gkizas, Vasilios
Davlouros, Periklis
Akinosoglou, Karolina
Leopoulou, Marianna
Gogos, Charalampos
Alexopoulos, Dimitrios
description Background Thalassemic patients demonstrate an increased rate of extracardiae vascular complications and increased carotid wall intima-media thickness （cIMT）, but very low prevalence of coronary artery disease （CAD）. We investigated the atheroma burden by assessing the coronary artery calcium （CAC） and elMT in these patients. Methods We examined 37 patients with β-thalassemia and 150 healthy control volunteers with multi-detector computer tomography （CT） and ultrasonography to determine CAC score and cIMT, respectively. Results Propensity score matching （C-statistic： 0.88; 95% CI： 0.83-0.93） resulted in 27 pairs of patients; severe CAC was observed in 2 （7.4%） and 0 of β-thalassemia patients and healthy volunteers respectively （P = 0.5）. Median calcium score was 0 （0-0） in β-thalassemia patients and 0 （0-4） in healthy volunteers （P = 0.8）. Median intima-media thickness was higher in β-thalassemia patients compared to control group [0.45 （0.06-0.65） vs. 0.062 （0.054-0.086）; P = 0.04]. Conclusions Patients with β-thalassemia in comparison with healthy control subjects exhibit similar CAC score and increased cIMT. Our findings indicate a disparate rate of progression of atherosclerosis between coronary and extracardiac arteries in these patients lending support to the epidemiological evidence.
doi_str_mv 10.11909/j.issn.1671-5411.2016.02.006
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We investigated the atheroma burden by assessing the coronary artery calcium （CAC） and elMT in these patients. Methods We examined 37 patients with β-thalassemia and 150 healthy control volunteers with multi-detector computer tomography （CT） and ultrasonography to determine CAC score and cIMT, respectively. Results Propensity score matching （C-statistic： 0.88; 95% CI： 0.83-0.93） resulted in 27 pairs of patients; severe CAC was observed in 2 （7.4%） and 0 of β-thalassemia patients and healthy volunteers respectively （P = 0.5）. Median calcium score was 0 （0-0） in β-thalassemia patients and 0 （0-4） in healthy volunteers （P = 0.8）. Median intima-media thickness was higher in β-thalassemia patients compared to control group [0.45 （0.06-0.65） vs. 0.062 （0.054-0.086）; P = 0.04]. Conclusions Patients with β-thalassemia in comparison with healthy control subjects exhibit similar CAC score and increased cIMT. Our findings indicate a disparate rate of progression of atherosclerosis between coronary and extracardiac arteries in these patients lending support to the epidemiological evidence.</description><identifier>ISSN: 1671-5411</identifier><identifier>DOI: 10.11909/j.issn.1671-5411.2016.02.006</identifier><identifier>PMID: 27168742</identifier><language>eng</language><publisher>China: Cardiology Department of Patras University Hospital,Patras,Greece%Radiology Department of Patras University Hospital,Patras,Greece</publisher><subject>冠状动脉粥样硬化 ; 地中海贫血 ; 患者 ; 膜厚度 ; 计算机断层扫描 ; 评分 ; 钙化 ; 颈动脉</subject><ispartof>Journal of geriatric cardiology : JGC, 2016-02, Vol.13 (2), p.158-162</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>Institute of Geriatric Cardiology 2016</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/88644X/88644X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854955/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854955/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27168742$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hahalis, George</creatorcontrib><creatorcontrib>Zacharioglou, Evangelia</creatorcontrib><creatorcontrib>Xanthopoulou, Ioanna</creatorcontrib><creatorcontrib>Koniari, Ioanna</creatorcontrib><creatorcontrib>Kalogeropoulou, Chistina</creatorcontrib><creatorcontrib>Tsota, Irene</creatorcontrib><creatorcontrib>Rigopoulou, Aspasia</creatorcontrib><creatorcontrib>Diamantopoulos, Athanasios</creatorcontrib><creatorcontrib>Gkizas, Vasilios</creatorcontrib><creatorcontrib>Davlouros, Periklis</creatorcontrib><creatorcontrib>Akinosoglou, Karolina</creatorcontrib><creatorcontrib>Leopoulou, Marianna</creatorcontrib><creatorcontrib>Gogos, Charalampos</creatorcontrib><creatorcontrib>Alexopoulos, Dimitrios</creatorcontrib><title>Coronary atherosclerosis burden is not advanced in patients with β-thalassemia despite premature extracardiac atherosclerosis： a coronary artery calcium score and carotid intima-media thickness study</title><title>Journal of geriatric cardiology : JGC</title><addtitle>Journal of Geriatric Cardiology</addtitle><description>Background Thalassemic patients demonstrate an increased rate of extracardiae vascular complications and increased carotid wall intima-media thickness （cIMT）, but very low prevalence of coronary artery disease （CAD）. We investigated the atheroma burden by assessing the coronary artery calcium （CAC） and elMT in these patients. Methods We examined 37 patients with β-thalassemia and 150 healthy control volunteers with multi-detector computer tomography （CT） and ultrasonography to determine CAC score and cIMT, respectively. Results Propensity score matching （C-statistic： 0.88; 95% CI： 0.83-0.93） resulted in 27 pairs of patients; severe CAC was observed in 2 （7.4%） and 0 of β-thalassemia patients and healthy volunteers respectively （P = 0.5）. Median calcium score was 0 （0-0） in β-thalassemia patients and 0 （0-4） in healthy volunteers （P = 0.8）. Median intima-media thickness was higher in β-thalassemia patients compared to control group [0.45 （0.06-0.65） vs. 0.062 （0.054-0.086）; P = 0.04]. Conclusions Patients with β-thalassemia in comparison with healthy control subjects exhibit similar CAC score and increased cIMT. 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We investigated the atheroma burden by assessing the coronary artery calcium （CAC） and elMT in these patients. Methods We examined 37 patients with β-thalassemia and 150 healthy control volunteers with multi-detector computer tomography （CT） and ultrasonography to determine CAC score and cIMT, respectively. Results Propensity score matching （C-statistic： 0.88; 95% CI： 0.83-0.93） resulted in 27 pairs of patients; severe CAC was observed in 2 （7.4%） and 0 of β-thalassemia patients and healthy volunteers respectively （P = 0.5）. Median calcium score was 0 （0-0） in β-thalassemia patients and 0 （0-4） in healthy volunteers （P = 0.8）. Median intima-media thickness was higher in β-thalassemia patients compared to control group [0.45 （0.06-0.65） vs. 0.062 （0.054-0.086）; P = 0.04]. Conclusions Patients with β-thalassemia in comparison with healthy control subjects exhibit similar CAC score and increased cIMT. Our findings indicate a disparate rate of progression of atherosclerosis between coronary and extracardiac arteries in these patients lending support to the epidemiological evidence.</abstract><cop>China</cop><pub>Cardiology Department of Patras University Hospital,Patras,Greece%Radiology Department of Patras University Hospital,Patras,Greece</pub><pmid>27168742</pmid><doi>10.11909/j.issn.1671-5411.2016.02.006</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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subjects 冠状动脉粥样硬化
地中海贫血
患者
膜厚度
计算机断层扫描
评分
钙化
颈动脉
title Coronary atherosclerosis burden is not advanced in patients with β-thalassemia despite premature extracardiac atherosclerosis： a coronary artery calcium score and carotid intima-media thickness study
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