Spatial-Temporal Co-Circulation of Dengue Virus 1, 2, 3, and 4 Associated with Coinfection Cases in a Hyperendemic Area of Brazil: A 4-Week Survey

Dengue is currently regarded as a major public health problem worldwide. In a hyperendemic region during an outbreak, we detected the co-circulation of all Dengue virus (DENV) serotypes including two different genotypes of DENV-3 and DENV-4, and concurrent infections with up to three serotypes were...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2016-05, Vol.94 (5), p.1080-1084
Main Authors: Andrade, Elisa H P, Figueiredo, Leandra B, Vilela, Ana P P, Rosa, Júlio C C, Oliveira, Jaquelline G, Zibaoui, Hassan M, Araújo, Valdelaine E M, Miranda, Daniela P J, Ferreira, Paulo C P, Abrahão, Jonatas S, Kroon, Erna G
Format: Article
Language:English
Subjects:
Brazil - epidemiology
Coinfection
Dengue - epidemiology
Dengue - virology
Dengue Virus - classification
Dengue Virus - genetics
Dengue virus type 1
Endemic Diseases
Humans
Time Factors
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Summary:Dengue is currently regarded as a major public health problem worldwide. In a hyperendemic region during an outbreak, we detected the co-circulation of all Dengue virus (DENV) serotypes including two different genotypes of DENV-3 and DENV-4, and concurrent infections with up to three serotypes were identified in symptomatic patients. A total of 49 acute phase plasma samples from patients clinically suspected of dengue were collected during the 4 weeks of May 2013. DENV-1-4 was detected by reverse transcriptase semi-nested polymerase chain reaction in 33 samples (67.3%), of which 26 DNA fragments were sequenced. Twenty samples (76.9%) were identified with a single DENV serotype and six (23.1%) with more than one serotype. DENV-3 was the predominant serotype of the outbreak. On the basis of phylogenetic analyses, DENV-1 isolates belong to genotype V, DENV-2 to American-Asian genotype, DENV-3 to genotypes I and III, and DENV-4 to genotypes I and II.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.15-0892