Absence of cytoglobin promotes multiple organ abnormalities in aged mice

Cytoglobin (Cygb) was identified in hepatic stellate cells (HSCs) and pericytes of all organs; however, the effects of Cygb on cellular functions remain unclear. Here, we report spontaneous and age-dependent malformations in multiple organs of Cygb −/− mice. Twenty-six percent of young Cygb −/− mice...

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Bibliographic Details
Published in:Scientific reports 2016-05, Vol.6 (1), p.24990-24990, Article 24990
Main Authors: Thuy, Le Thi Thanh, Van Thuy, Tuong Thi, Matsumoto, Yoshinari, Hai, Hoang, Ikura, Yoshihiro, Yoshizato, Katsutoshi, Kawada, Norifumi
Format: Article
Language:English
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Age
Aging
Animal Structures - pathology
Animals
Antioxidants
Arginine
Cancer
Coronary artery disease
DNA damage
Fibrosis
Globins - deficiency
Heart diseases
Humanities and Social Sciences
Hypertrophy
Interleukin 6
Kidneys
Lymphoma
Metabolites
Mice
Monomethyl-L-arginine
mRNA
multidisciplinary
Nitric oxide
Oxidative Stress
Pericytes
Reactive Nitrogen Species - analysis
Rodents
Science
Senescence
Stellate cells
Urine
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Summary:Cytoglobin (Cygb) was identified in hepatic stellate cells (HSCs) and pericytes of all organs; however, the effects of Cygb on cellular functions remain unclear. Here, we report spontaneous and age-dependent malformations in multiple organs of Cygb −/− mice. Twenty-six percent of young Cygb −/− mice (
ISSN:2045-2322
2045-2322
DOI:10.1038/srep24990