Canine Pancreatic‐Specific Lipase Concentrations in Clinically Healthy Dogs and Dogs with Naturally Occurring Hyperadrenocorticism

• Published in: Journal of veterinary internal medicine 2014-07, Vol.28 (4), p.1244-1250
• Main Authors: Mawby, D.I, Whittemore, J.C, Fecteau, K.A
• Format: Article
• Language: English
• Subjects: Adrenocortical Hyperfunction - complications; Adrenocortical Hyperfunction - enzymology; Adrenocortical Hyperfunction - veterinary; Animals; Biomarkers - blood; blood serum; Case-Control Studies; correlation; corticotropin; Cortisol; Cushings; Dog Diseases - enzymology; Dogs; Enzyme-Linked Immunosorbent Assay - veterinary; Enzymes; Female; hyperadrenocorticism; Lipase - blood; Male; medicine; Original; Pancreas; Pancreatitis; Pancreatitis - enzymology; Pancreatitis - etiology; Pancreatitis - veterinary; Point-of-Care Systems; Potassium; Steroids; triacylglycerol lipase
• ISSN: 0891-6640; 1939-1676
• DOI: 10.1111/jvim.12376

BACKGROUND: Specificity of canine pancreatic lipase immunoreactivity (cPLI) assays in dogs with hyperadrenocorticism (HAC) is unknown. HYPOTHESIS: Results of cPLI assays differ for clinically healthy dogs and dogs with HAC. ANIMALS: Seventeen healthy dogs and 20 dogs with HAC diagnosed by ACTH stimulation test results without evidence of clinical pancreatitis. METHODS: Dogs were enrolled between December 2009 and November 2010. Serum cPLI concentrations were determined by quantitative (Spec cPL test, SPEC) and semiquantitative (SNAP cPL test, SNAP) assays. Results were categorized as normal, equivocal, or abnormal (SPEC) or negative or positive (SNAP). Associations between group and cPLI were assessed using Fisher's exact test or the Mann–Whitney U‐test. Spearman rank correlation coefficients (ρ) were determined for SNAP and SPEC results. Significance was set at P