Glycemic Status and Predictors of Relapse for Diabetic Cats in Remission

Background It is unknown if diabetic cats in remission have persistent abnormalities of glucose metabolism and should be considered prediabetic, or have normal glucose tolerance. Objective To characterize glycemic status of diabetic cats in remission and to determine predictors of relapse. Animals A...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2015-01, Vol.29 (1), p.184-192
Main Authors: Gottlieb, S., Rand, J.S., Marshall, R., Morton, J.
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - adverse effects
Aging
Animals
Blood Glucose - physiology
Blood levels
Cat Diseases - blood
Catheters
Cats
Chromium
Diabetes
Diabetes mellitus
Diabetes Mellitus - blood
Diabetes Mellitus - veterinary
Fasting
Female
Glucose
Glucose Intolerance
Glucose metabolism
Glucose tolerance
Glucose tolerance test
Hyperglycemia
Impaired fasting glucose concentration
Impaired glucose tolerance
Insulin
Intolerance
Laboratories
Laboratory testing
Lipase
Lipase - blood
Lipase - metabolism
Male
Pancreas
Pancreas - enzymology
Pancreatitis - blood
Pancreatitis - veterinary
Prediabetic
Recurrence
Remission
Remission, Spontaneous
Screening glucose
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Summary:Background It is unknown if diabetic cats in remission have persistent abnormalities of glucose metabolism and should be considered prediabetic, or have normal glucose tolerance. Objective To characterize glycemic status of diabetic cats in remission and to determine predictors of relapse. Animals A total of 21 cats in diabetic remission and 28 healthy control cats. Methods At a median of 107 days after remission, screening blood glucose concentration was measured on entry to the clinic. After a 24‐hour fast in hospital, fasting blood glucose, fructosamine and feline pancreatic lipase concentrations were measured, and 3 hours later, a simplified IV glucose tolerance test (1 g glucose/kg) performed. Twenty cats were monitored for relapse for at least 9 months. Results Of the 21 cats in remission, 19% (4/21) had impaired fasting glucose concentration and 76% (16/21) had impaired glucose tolerance. Of cats followed up for 9 months after testing, 30% (6/20) had relapsed and required insulin treatment. Fasting blood glucose concentration ≥7.5 mmol/L (≥135 mg/dL) (odds ratio [OR] = 12.8) and severely impaired glucose tolerance (≥5 hours to return to
ISSN:0891-6640
1939-1676
DOI:10.1111/jvim.12509