Hyperbaric oxygen therapy stimulates colonic stem cells and induces mucosal healing in patients with refractory ulcerative colitis: a prospective case series

BackgroundHyperbaric oxygen (HBO) is used as part of treatment in a variety of clinical conditions. Its use in the treatment of ulcerative colitis has been reported in few clinical reports.ObjectiveWe report the effect of HBO on refractory ulcerative colitis exploring one potential mechanism of acti...

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Bibliographic Details
Published in:BMJ open gastroenterology 2016-01, Vol.3 (1), p.e000082-e000082
Main Authors: Bekheit, Mohamed, Baddour, Nahed, Katri, Khaled, Taher, Yousry, El Tobgy, Khaled, Mousa, Essam
Format: Article
Language:English
Subjects:
Biopsy
Colon
Endoscopy
Inflammation
Inflammatory Bowel Disease
Laboratory animals
Oxygen therapy
Patients
Respiratory therapy
Stem cells
Ulcers
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Summary:BackgroundHyperbaric oxygen (HBO) is used as part of treatment in a variety of clinical conditions. Its use in the treatment of ulcerative colitis has been reported in few clinical reports.ObjectiveWe report the effect of HBO on refractory ulcerative colitis exploring one potential mechanism of action.DesignA review of records of patients with refractory ulcerative colitis who received HBO was conducted. Clinical and histopathological scoring was utilised to evaluate the response to HBO therapy (HBOT).ResultsAll patients manifested clinical improvement by the 40th cycle of HBOT. The median number of stool frequency dropped from seven motions/day (range=3–20) to 1/day (range=0.5–3), which was significant (z=−4.6, p
ISSN:2054-4774
2054-4774
DOI:10.1136/bmjgast-2016-000082