Serologic evidence for hepatitis E virus infection among patients with undifferentiated acute febrile illness in Kibera, Kenya

Highlights • Hepatitis E (HEV) diagnosis consists of indirect testing with enzyme immunoassays and direct testing with nucleic acid testing (NAT). • Serologic evidence suggests a high level of HEV infection among persons with undifferentiated AFI in Kibera. • NAT did not corroborate a high level of...

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Bibliographic Details
Published in:Journal of clinical virology 2016-04, Vol.77, p.106-108
Main Authors: Furukawa, N.W, Teshale, E.H, Cosmas, L, Ochieng, M, Gikunju, S, Fields, B.S, Montgomery, J.M
Format: Article
Language:English
Subjects:
Acute febrile illness
Allergy and Immunology
Antibodies, Viral - blood
Antibodies, Viral - immunology
Cross-Sectional Studies
Enzyme immunoassay
Fever - epidemiology
Hepatitis E
Hepatitis E - epidemiology
Hepatitis E - immunology
Hepatitis E - virology
Hepatitis E virus
Hepatitis E virus - immunology
Human immunodeficiency virus
Humans
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunoglobulin M - blood
Immunoglobulin M - immunology
Infectious Disease
Kenya
Kenya - epidemiology
Kibera
Nucleic acid testing
Serologic Tests
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Summary:Highlights • Hepatitis E (HEV) diagnosis consists of indirect testing with enzyme immunoassays and direct testing with nucleic acid testing (NAT). • Serologic evidence suggests a high level of HEV infection among persons with undifferentiated AFI in Kibera. • NAT did not corroborate a high level of HEV infection among our AFI sample population. • Serologic HEV testing in a population with undifferentiated AFI may yield false positives due to cross-reactivity from other infectious agents.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2016.02.021