Electrophysiological evidence for flexible goal-directed cue processing during episodic retrieval

• Published in: NeuroImage (Orlando, Fla.) Fla.), 2016-05, Vol.132, p.24-31
• Main Authors: Herron, Jane E., Evans, Lisa H., Wilding, Edward L.
• Format: Article
• Language: English
• Subjects: Accuracy; Adolescent; Adult; Bias; Cerebral Cortex - physiology; Content specificity; Cue processing; Cues; Electroencephalography; Episodic memory; Event-related potentials; Evoked Potentials; Executive Function - physiology; Female; Goals; Humans; Male; Memory; Memory, Episodic; Mental Recall - physiology; Preparatory processing; Retrieval orientation; Studies; Task-switching; Young Adult
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2016.02.025

A widely held assumption is that memory retrieval is aided by cognitive control processes that are engaged flexibly in service of memory retrieval and memory decisions. While there is some empirical support for this view, a notable exception is the absence of evidence for the flexible use of retrieval control in functional neuroimaging experiments requiring frequent switches between tasks with different cognitive demands. This absence is troublesome in so far as frequent switches between tasks mimic some of the challenges that are typically placed on memory outside the laboratory. In this experiment we instructed participants to alternate frequently between three episodic memory tasks requiring item recognition or retrieval of one of two different kinds of contextual information encoded in a prior study phase (screen location or encoding task). Event-related potentials (ERPs) elicited by unstudied items in the two tasks requiring retrieval of study context were reliably different, demonstrating for the first time that ERPs index task-specific processing of retrieval cues when retrieval goals change frequently. The inclusion of the item recognition task was a novel and important addition in this study, because only the ERPs elicited by unstudied items in one of the two context conditions diverged from those in the item recognition condition. This outcome constrains functional interpretations of the differences that emerged between the two context conditions and emphasises the utility of this baseline in functional imaging studies of retrieval processing operations. [Display omitted] •Three different episodic memory tasks were intermixed.•Event-related potential correlates of unstudied retrieval cues were analysed by task.•Neural correlates of these items differed according to retrieval task.•Novel ERP evidence for flexible task-dependent processing of retrieval cues.