Clinical Significance of the Prognostic Nutritional Index for Predicting Short- and Long-Term Surgical Outcomes After Gastrectomy: A Retrospective Analysis of 7781 Gastric Cancer Patients

To evaluate the predictive and prognostic significance of the prognostic nutritional index (PNI) in a large cohort of gastric cancer patients who underwent gastrectomy.Assessing a patient's immune and nutritional status, PNI has been reported as a predictive marker for surgical outcomes in vari...

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Published in:Medicine (Baltimore) 2016-05, Vol.95 (18), p.e3539-e3539
Main Authors: Lee, Jee Youn, Kim, Hyoung-Il, Kim, You-Na, Hong, Jung Hwa, Alshomimi, Saeed, An, Ji Yeong, Cheong, Jae-Ho, Hyung, Woo Jin, Noh, Sung Hoon, Kim, Choong-Bai
Format: Article
Language:English
Subjects:
Female
Gastrectomy - adverse effects
Gastrectomy - methods
Humans
Kaplan-Meier Estimate
Long Term Adverse Effects - diagnosis
Long Term Adverse Effects - etiology
Male
Middle Aged
Nutrition Assessment
Nutritional Status
Observational Study
Postoperative Complications - diagnosis
Predictive Value of Tests
Prognosis
Republic of Korea
Retrospective Studies
Risk Factors
Stomach Neoplasms - diagnosis
Stomach Neoplasms - surgery
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Summary:To evaluate the predictive and prognostic significance of the prognostic nutritional index (PNI) in a large cohort of gastric cancer patients who underwent gastrectomy.Assessing a patient's immune and nutritional status, PNI has been reported as a predictive marker for surgical outcomes in various types of cancer.We retrospectively reviewed data from a prospectively maintained database of 7781 gastric cancer patients who underwent gastrectomy from January 2001 to December 2010 at a single center. From this data, we analyzed clinicopathologic characteristics, PNI, and short- and long-term surgical outcomes for each patient. We used the PNI value for the 10th percentile (46.70) of the study cohort as a cut-off for dividing patients into low and high PNI groups.Regarding short-term outcomes, multivariate analysis showed a low PNI (odds ratio [OR] = 1.505, 95% CI = 1.212-1.869, P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000003539