Carotid Atherosclerosis Progression and Risk of Cardiovascular Events in a Community in Taiwan

The authors investigated the association between progression of carotid atherosclerosis and incidence of cardiovascular disease in a community cohort in Taiwan. Data has rarely been reported in Asian populations. Study subjects were 1,398 participants who underwent ultrasound measures of common caro...

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Bibliographic Details
Published in:Scientific reports 2016-05, Vol.6 (1), p.25733-25733, Article 25733
Main Authors: Chen, Pei-Chun, Jeng, Jiann-Shing, Hsu, Hsiu-Ching, Su, Ta-Chen, Chien, Kuo-Liong, Lee, Yuan-Teh
Format: Article
Language:English
Subjects:
692/53
692/699/75
Cardiovascular Diseases - pathology
Carotid Artery Diseases - pathology
Carotid Intima-Media Thickness
Disease Progression
Endpoint Determination
Female
Follow-Up Studies
Humanities and Social Sciences
Humans
Male
Middle Aged
multidisciplinary
Plaque, Atherosclerotic - pathology
Proportional Hazards Models
Risk Factors
Science
Science (multidisciplinary)
Taiwan
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Summary:The authors investigated the association between progression of carotid atherosclerosis and incidence of cardiovascular disease in a community cohort in Taiwan. Data has rarely been reported in Asian populations. Study subjects were 1,398 participants who underwent ultrasound measures of common carotid artery intima-media thickness (IMT) and extracranial carotid artery plaque score at both 1994–1995 and 1999–2000 surveys. Cox proportional hazards model was used to assess the risk of incident cardiovascular disease. During a median follow-up of 13 years (1999–2013), 71 strokes and 68 coronary events occurred. The 5-year individual IMT change was not associated with development of cardiovascular events in unadjusted and adjusted models. Among subjects without plaque in 1994–1995, we observed elevated risk associated with presence of new plaque (plaque score >0 in 1999–2000) in a dose-response manner in unadjusted and age- and sex- adjusted models. The associations attenuated and became statistically non-significant after controlling for cardiovascular risk factors (hazard ratio [95% confidence interval] for plaque score >2 vs. 0: stroke, 1.61 [0.79–3.27], coronary events, 1.13 [0.48–2.69]). This study suggested that carotid plaque formation measured by ultrasound is associated increased risk of developing cardiovascular disease, and cardiovascular risk factors explain the associations to a large extent.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep25733