Neoadjuvant chemotherapy for locally advanced cervical cancer

Neoadjuvant chemotherapy followed by surgery （NCS） has not been fully evaluated clinically. Currently, the main regimen of neoadjuvant chemotherapy （NAC） used in NCS includes cisplatin. The antitumor effects of NAC reduce lymph node metastasis and the tumor diameter in patients prior to surgery, and...

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Published in:Chinese journal of cancer research 2016-04, Vol.28 (2), p.235-240
Main Authors: Iwata, Takashi, Miyauchi, Azumi, Suga, Yukako, Nishio, Hiroshi, Nakamura, Masaru, Ohno, Akiko, Hirao, Nobumaru, Morisada, Tohru, Tanaka, Kyoko, Ueyama, Hiroki, Watari, Hidemichi, Aoki, Daisuke
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Language:English
Subjects:
NCS
Review on Cervical Cancer
化疗
宫颈癌
抗肿瘤作用
放射治疗
晚期
随机对照试验
验证系统
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container_issue 2
container_start_page 235
container_title Chinese journal of cancer research
container_volume 28
creator Iwata, Takashi
Miyauchi, Azumi
Suga, Yukako
Nishio, Hiroshi
Nakamura, Masaru
Ohno, Akiko
Hirao, Nobumaru
Morisada, Tohru
Tanaka, Kyoko
Ueyama, Hiroki
Watari, Hidemichi
Aoki, Daisuke
description Neoadjuvant chemotherapy followed by surgery （NCS） has not been fully evaluated clinically. Currently, the main regimen of neoadjuvant chemotherapy （NAC） used in NCS includes cisplatin. The antitumor effects of NAC reduce lymph node metastasis and the tumor diameter in patients prior to surgery, and this can reduce the number of high risk patients who require postoperative radiation therapy. Many randomized controlled trials （RCTs） have examined the long-term prognosis of NCS compared to primary surgery, but the utility of NCS remains uncertain. The advent of concurrent chemoradiotherapy （CCRT） has markedly improved the outcome of radiotherapy （RT）, and CCRT is now used as a standard method in many cases of advanced bulky cervical cancer. NCS gives a better treatment outcome than radiation therapy alone, but it is important to verify that NCS gives a similar or better outcome compared to CCRT.
doi_str_mv 10.21147/j.issn.1000-9604.2016.02.13
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subjects NCS
Review on Cervical Cancer
化疗
宫颈癌
抗肿瘤作用
放射治疗
晚期
随机对照试验
验证系统
title Neoadjuvant chemotherapy for locally advanced cervical cancer
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