Circulating Zinc-α2-glycoprotein levels and Insulin Resistance in Polycystic Ovary Syndrome

The aim of study was to assess the relationship between zinc-α2-glycoprotein (ZAG) and androgen excess with insulin resistance in polycystic ovary syndrome (PCOS) women. 99 PCOS women and 100 healthy controls were recruited. Euglycemic-hyperinsulinemic clamp (EHC) was preformed to assess their insul...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2016-05, Vol.6 (1), p.25934-25934, Article 25934
Main Authors: Lai, Yerui, Chen, Jinhua, Li, Ling, Yin, Jingxia, He, Junying, Yang, Mengliu, Jia, Yanjun, Liu, Dongfang, Liu, Hua, Liao, Yong, Yang, Gangyi
Format: Article
Language:English
Subjects:
692/53/2421
692/699/2743/137/773
82
82/1
82/80
Adult
Area Under Curve
Blood Glucose - analysis
Case-Control Studies
Circadian Rhythm
Cross-Sectional Studies
Female
Humanities and Social Sciences
Humans
Insulin Resistance
multidisciplinary
Obesity - blood
Overweight - blood
Polycystic Ovary Syndrome - blood
Science
Science (multidisciplinary)
Seminal Plasma Proteins - blood
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of study was to assess the relationship between zinc-α2-glycoprotein (ZAG) and androgen excess with insulin resistance in polycystic ovary syndrome (PCOS) women. 99 PCOS women and 100 healthy controls were recruited. Euglycemic-hyperinsulinemic clamp (EHC) was preformed to assess their insulin sensitivity. Circulating ZAG was determined with an ELISA kit. In healthy subjects, circulating ZAG levels exhibited a characteristic diurnal rhythm in humans, with a major nocturnal rise occurring between midnight and early morning. Circulating ZAG and M-value were much lower in PCOS women than in the controls. In all population, overweight/obese subjects had significantly lower circulating ZAG levels than lean individuals. Multiple linear regression analysis revealed that only M-value and the area under the curve for glucose were independently related factors to circulating ZAG in PCOS women. Multivariate logistic regression analysis showed that circulating ZAG was significantly associated with PCOS even after controlling for anthropometric variables, blood pressure, lipid profile and hormone levels. The PCOS women with high ZAG had fewer MetS, IGT and polycystic ovaries as compared with the low ZAG PCOS women. Taken together, circulating ZAG levels are reduced in women with PCOS and ZAG may be a cytokine associated with insulin resistance in PCOS women.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep25934