Trop2 is overexpressed in gastric cancer and predicts poor prognosis

The cell surface protein Trop2 is overexpressed in a variety of human cancers. Trop2 expression increases tumor development and metastasis and reduces patient survival. However, little is known about the role of Trop2 expression and its prognostic value in gastric cancer (GC), particularly in Chines...

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Bibliographic Details
Published in:Oncotarget 2016-02, Vol.7 (5), p.6136-6145
Main Authors: Zhao, Wei, Zhu, Huijun, Zhang, Shu, Yong, Hongmei, Wang, Wei, Zhou, Yan, Wang, Bing, Wen, Jinbo, Qiu, Zhenning, Ding, Guipeng, Feng, Zhenqing, Zhu, Jin
Format: Article
Language:English
Subjects:
Antigens, Neoplasm - biosynthesis
Antigens, Neoplasm - genetics
Biomarkers, Tumor - biosynthesis
Biomarkers, Tumor - genetics
Cell Adhesion Molecules - biosynthesis
Cell Adhesion Molecules - genetics
Female
Humans
Immunohistochemistry
Male
Middle Aged
Prognosis
Real-Time Polymerase Chain Reaction
Research Paper
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Survival Analysis
Tissue Array Analysis - methods
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Summary:The cell surface protein Trop2 is overexpressed in a variety of human cancers. Trop2 expression increases tumor development and metastasis and reduces patient survival. However, little is known about the role of Trop2 expression and its prognostic value in gastric cancer (GC), particularly in Chinese populations. We analyzed Trop2 expression in GC tissues collected from Chinese GC patients. Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry on tissue microarrays were performed to assess levels of Trop2 mRNA and protein in GC, and correlations between Trop2 expression and clinical characteristics and prognosis were analyzed. Trop2 expression was higher in GC tissues than in neighboring non-tumor tissues. Increased Trop2 protein levels in GC were associated with increased differentiation, tumor node metastasis stage, tumor size, lymph node metastasis, distant metastasis, and H. pylori infection. GC patients with high Trop2 expression also had poor overall survival rates. These data suggest Trop2 is a useful prognostic biomarker for GC.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.6733