Genetic polymorphism analyses of a novel panel of 19 X-STR loci in the Chinese Uygur ethnic minority

The population genetic data and forensic parameters of 19 X-chromosome short tandem repeat (X-STR) loci in Chinese Uygur ethnic minority are presented. These loci were detected in a sample of 233 (94 males and 139 females) unrelated healthy individuals. We observed 238 alleles at the 19 X-STR loci,...

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Bibliographic Details
Published in:Journal of Zhejiang University. B. Science 2016-05, Vol.17 (5), p.367-374
Main Authors: Guo, Yu-xin, Chen, Jian-gang, Wang, Yan, Yan, Jiang-wei, Chen, Jing, Yao, Tian-hua, Zhang, Li-ping, Yang, Guang, Meng, Hao-tian, Zhang, Yu-dang, Mei, Ting, Liu, Yao-shun, Dong, Qian, Zhu, Bo-feng
Format: Article
Language:English
Subjects:
Algorithms
Alleles
Asian Continental Ancestry Group - genetics
Biomedical and Life Sciences
Biomedicine
China
Chromosomes, Human, X
Female
Females
Forensic engineering
Forensic science
Gene Frequency
Gene polymorphism
Genetic analysis
Genetics, Population
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Loci
Male
Males
Microsatellite Repeats
Minority & ethnic groups
Minority Groups
Polymerase Chain Reaction
Polymorphism
Polymorphism, Genetic
Population genetics
Probability
Sex Factors
X Chromosomes
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Summary:The population genetic data and forensic parameters of 19 X-chromosome short tandem repeat (X-STR) loci in Chinese Uygur ethnic minority are presented. These loci were detected in a sample of 233 (94 males and 139 females) unrelated healthy individuals. We observed 238 alleles at the 19 X-STR loci, with the corresponding gene frequencies spanning the range from 0.0021 to 0.5644. After Bonferroni correction ( P >0.0026), there were no significant deviations from Hardy-Weinberg equilibrium. The cumulative power of discrimination in females and males, and the probability of exclusion of the 19 X-STR loci were 0.999 999 999 999 999 999 998 091, 0.999 999 999 999 966, and 0.999 999 986 35, respectively. The cumulative mean exclusion chance was 0.999 999 992 849 in deficiency cases, 0.999 999 999 999 628 in normal trios, and 0.999 999 998 722 in duo cases. The high value of the forensic parameters mentioned above revealed that the novel panel of 19 loci had important values for forensic applications in the Uygur group.
ISSN:1673-1581
1862-1783
DOI:10.1631/jzus.B1500228