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The evaluation of three treatments for plantar callus: a three-armed randomised, comparative trial using biophysical outcome measures
Callus is one of the most common foot skin complaints experienced by people of all ages. These painful and unsightly lesions often result in disability. The 'gold standard' of treatment is scalpel debridement by a trained specialist; however, people also seek over-the-counter remedies. The...
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| Published in: | Current controlled trials in cardiovascular medicine 2016-05, Vol.17 (1), p.251, Article 251 |
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| creator | Hashmi, Farina Nester, Christopher J Wright, Ciaran R F Lam, Sharon |
| description | Callus is one of the most common foot skin complaints experienced by people of all ages. These painful and unsightly lesions often result in disability. The 'gold standard' of treatment is scalpel debridement by a trained specialist; however, people also seek over-the-counter remedies. There is a lack of clinical evidence for the efficacy of such products, which makes selection by patients and practitioners difficult.
This randomised, three-armed, parallel, comparative trial aimed to test the efficacy of two home treatments for plantar callus using novel, objective outcome measures (skin hydration using the capacitance method; elasticity using negative pressure application; and surface texture using imaging). Additional outcome measures were: size of callus, quality of life (Foot Health Status Questionnaire) and self-reported participant satisfaction and compliance. The results were compared to a podiatry treatment. Participants were randomly allocated to one of three groups: potassium hydroxide (KOH, 40 %); trichloroacetic acid (TCA); and podiatry treatment. Participants were followed for 3 weeks after their initial intervention appointment (days 7, 14 and 21). The primary outcomes were the change from baseline in callus hydration, elasticity, texture, and size at each of the three time points. The secondary outcomes where: change in quality of life 21 days after treatment; resolution of calluses via visual inspection; and participant compliance and perception.
Forty-six participants (61 ft) with plantar calluses were recruited. The podiatry treatment showed immediate and significant changes in all objective outcomes, associated foot pain and function (p |
| doi_str_mv | 10.1186/s13063-016-1377-2 |
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This randomised, three-armed, parallel, comparative trial aimed to test the efficacy of two home treatments for plantar callus using novel, objective outcome measures (skin hydration using the capacitance method; elasticity using negative pressure application; and surface texture using imaging). Additional outcome measures were: size of callus, quality of life (Foot Health Status Questionnaire) and self-reported participant satisfaction and compliance. The results were compared to a podiatry treatment. Participants were randomly allocated to one of three groups: potassium hydroxide (KOH, 40 %); trichloroacetic acid (TCA); and podiatry treatment. Participants were followed for 3 weeks after their initial intervention appointment (days 7, 14 and 21). The primary outcomes were the change from baseline in callus hydration, elasticity, texture, and size at each of the three time points. The secondary outcomes where: change in quality of life 21 days after treatment; resolution of calluses via visual inspection; and participant compliance and perception.
Forty-six participants (61 ft) with plantar calluses were recruited. The podiatry treatment showed immediate and significant changes in all objective outcomes, associated foot pain and function (p <0.01). Lesser changes in skin quality and perceived pain and functional benefits occurred with TCA and KOH over 21 days.
This is the first study where objective outcome measures have been used to measure changes in the nature of skin in response to callus treatments. We found significant differences in plantar callus in response to podiatry and two home treatments. The podiatry treatment showed immediate and significant changes in skin and associated foot pain and function. Lesser, but sometimes comparable, changes in skin and perceived pain and functional benefits occurred with TCA and KOH over 21 days.
ISRCTN14751843 : date of registration: 30 April 2015.</description><identifier>ISSN: 1745-6215</identifier><identifier>EISSN: 1745-6215</identifier><identifier>DOI: 10.1186/s13063-016-1377-2</identifier><identifier>PMID: 27189190</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Administration, Cutaneous ; Adult ; Aged ; Analysis ; Callosities ; Callosities - diagnosis ; Callosities - physiopathology ; Callosities - therapy ; Care and treatment ; Caustics - administration & dosage ; Caustics - adverse effects ; Debridement ; Debridement - adverse effects ; Diabetes ; Diagnosis ; Elasticity ; England ; Female ; Foot diseases ; Foot Diseases - diagnosis ; Foot Diseases - physiopathology ; Foot Diseases - therapy ; Humans ; Hydration ; Hydroxides - administration & dosage ; Hydroxides - adverse effects ; Male ; Middle Aged ; Older people ; Pain Measurement ; Patient Compliance ; Patient Satisfaction ; Podiatry - methods ; Potash ; Potassium ; Potassium Compounds - administration & dosage ; Potassium Compounds - adverse effects ; Quality of Life ; Risk factors ; Skin ; Skin - metabolism ; Skin - pathology ; Skin - physiopathology ; Skin Physiological Phenomena ; Surveys and Questionnaires ; Time Factors ; Treatment Outcome ; Trichloroacetic Acid - administration & dosage ; Trichloroacetic Acid - adverse effects ; Water - metabolism ; Young Adult</subject><ispartof>Current controlled trials in cardiovascular medicine, 2016-05, Vol.17 (1), p.251, Article 251</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Hashmi et al. 2016. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Hashmi et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-5b80e70a4084821c7f2d3195f410a9bfe064bbdb25bc00d779d1e4a7ade01a343</citedby><cites>FETCH-LOGICAL-c494t-5b80e70a4084821c7f2d3195f410a9bfe064bbdb25bc00d779d1e4a7ade01a343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869362/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869362/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27189190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hashmi, Farina</creatorcontrib><creatorcontrib>Nester, Christopher J</creatorcontrib><creatorcontrib>Wright, Ciaran R F</creatorcontrib><creatorcontrib>Lam, Sharon</creatorcontrib><title>The evaluation of three treatments for plantar callus: a three-armed randomised, comparative trial using biophysical outcome measures</title><title>Current controlled trials in cardiovascular medicine</title><addtitle>Trials</addtitle><description>Callus is one of the most common foot skin complaints experienced by people of all ages. These painful and unsightly lesions often result in disability. The 'gold standard' of treatment is scalpel debridement by a trained specialist; however, people also seek over-the-counter remedies. There is a lack of clinical evidence for the efficacy of such products, which makes selection by patients and practitioners difficult.
This randomised, three-armed, parallel, comparative trial aimed to test the efficacy of two home treatments for plantar callus using novel, objective outcome measures (skin hydration using the capacitance method; elasticity using negative pressure application; and surface texture using imaging). Additional outcome measures were: size of callus, quality of life (Foot Health Status Questionnaire) and self-reported participant satisfaction and compliance. The results were compared to a podiatry treatment. Participants were randomly allocated to one of three groups: potassium hydroxide (KOH, 40 %); trichloroacetic acid (TCA); and podiatry treatment. Participants were followed for 3 weeks after their initial intervention appointment (days 7, 14 and 21). The primary outcomes were the change from baseline in callus hydration, elasticity, texture, and size at each of the three time points. The secondary outcomes where: change in quality of life 21 days after treatment; resolution of calluses via visual inspection; and participant compliance and perception.
Forty-six participants (61 ft) with plantar calluses were recruited. The podiatry treatment showed immediate and significant changes in all objective outcomes, associated foot pain and function (p <0.01). Lesser changes in skin quality and perceived pain and functional benefits occurred with TCA and KOH over 21 days.
This is the first study where objective outcome measures have been used to measure changes in the nature of skin in response to callus treatments. We found significant differences in plantar callus in response to podiatry and two home treatments. The podiatry treatment showed immediate and significant changes in skin and associated foot pain and function. Lesser, but sometimes comparable, changes in skin and perceived pain and functional benefits occurred with TCA and KOH over 21 days.
ISRCTN14751843 : date of registration: 30 April 2015.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Callosities</subject><subject>Callosities - diagnosis</subject><subject>Callosities - physiopathology</subject><subject>Callosities - therapy</subject><subject>Care and treatment</subject><subject>Caustics - administration & dosage</subject><subject>Caustics - adverse effects</subject><subject>Debridement</subject><subject>Debridement - adverse effects</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Elasticity</subject><subject>England</subject><subject>Female</subject><subject>Foot diseases</subject><subject>Foot Diseases - diagnosis</subject><subject>Foot Diseases - physiopathology</subject><subject>Foot Diseases - therapy</subject><subject>Humans</subject><subject>Hydration</subject><subject>Hydroxides - administration & dosage</subject><subject>Hydroxides - adverse effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Pain Measurement</subject><subject>Patient Compliance</subject><subject>Patient Satisfaction</subject><subject>Podiatry - methods</subject><subject>Potash</subject><subject>Potassium</subject><subject>Potassium Compounds - administration & dosage</subject><subject>Potassium Compounds - adverse effects</subject><subject>Quality of Life</subject><subject>Risk factors</subject><subject>Skin</subject><subject>Skin - metabolism</subject><subject>Skin - pathology</subject><subject>Skin - physiopathology</subject><subject>Skin Physiological Phenomena</subject><subject>Surveys and Questionnaires</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Trichloroacetic Acid - administration & dosage</subject><subject>Trichloroacetic Acid - adverse effects</subject><subject>Water - metabolism</subject><subject>Young Adult</subject><issn>1745-6215</issn><issn>1745-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptks1q3DAUhU1padK0D9BNEXRbp7qWLFldFELoTyCQTbIW1_L1jIJtuZI9kAfIe1fDpGkCQQsJ6ZyPc8Upio_ATwEa9TWB4EqUHFQJQuuyelUcg5Z1qSqoXz85HxXvUrrlXAoj5NviqNLQGDD8uLi_3hKjHQ4rLj5MLPRs2UYitkTCZaRpSawPkc0DTgtG5nAY1vSN4UFWYhypYxGnLow-UfeFuTDOGDNtt4d4HNia_LRhrQ_z9i75TGBhXbKM2EiY1kjpffGmxyHRh4f9pLj5-eP6_Hd5efXr4vzssnTSyKWs24aT5ih5I5sKnO6rToCpewkcTdsTV7Jtu7aqW8d5p7XpgCRq7IgDCilOiu8H7ry2ObfL40Uc7Bz9iPHOBvT2-cvkt3YTdlY2yghVZcDnB0AMf1ZKi70Na5xyZltpU1e1VNL8V21wIOunPmSYy__j7JlUooGm5pBVpy-o8upo9C5M1Pt8_8wAB4OLIaVI_WNw4HZfCHsohM2FsPtC2H3gT08nfnT8a4D4C92ds3g</recordid><startdate>20160517</startdate><enddate>20160517</enddate><creator>Hashmi, Farina</creator><creator>Nester, Christopher J</creator><creator>Wright, Ciaran R F</creator><creator>Lam, Sharon</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20160517</creationdate><title>The evaluation of three treatments for plantar callus: a three-armed randomised, comparative trial using biophysical outcome measures</title><author>Hashmi, Farina ; Nester, Christopher J ; Wright, Ciaran R F ; Lam, Sharon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-5b80e70a4084821c7f2d3195f410a9bfe064bbdb25bc00d779d1e4a7ade01a343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Administration, Cutaneous</topic><topic>Adult</topic><topic>Aged</topic><topic>Analysis</topic><topic>Callosities</topic><topic>Callosities - diagnosis</topic><topic>Callosities - physiopathology</topic><topic>Callosities - therapy</topic><topic>Care and treatment</topic><topic>Caustics - administration & dosage</topic><topic>Caustics - adverse effects</topic><topic>Debridement</topic><topic>Debridement - adverse effects</topic><topic>Diabetes</topic><topic>Diagnosis</topic><topic>Elasticity</topic><topic>England</topic><topic>Female</topic><topic>Foot diseases</topic><topic>Foot Diseases - diagnosis</topic><topic>Foot Diseases - physiopathology</topic><topic>Foot Diseases - therapy</topic><topic>Humans</topic><topic>Hydration</topic><topic>Hydroxides - administration & dosage</topic><topic>Hydroxides - adverse effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Pain Measurement</topic><topic>Patient Compliance</topic><topic>Patient Satisfaction</topic><topic>Podiatry - methods</topic><topic>Potash</topic><topic>Potassium</topic><topic>Potassium Compounds - administration & dosage</topic><topic>Potassium Compounds - adverse effects</topic><topic>Quality of Life</topic><topic>Risk factors</topic><topic>Skin</topic><topic>Skin - metabolism</topic><topic>Skin - pathology</topic><topic>Skin - physiopathology</topic><topic>Skin Physiological Phenomena</topic><topic>Surveys and Questionnaires</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Trichloroacetic Acid - administration & dosage</topic><topic>Trichloroacetic Acid - adverse effects</topic><topic>Water - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashmi, Farina</creatorcontrib><creatorcontrib>Nester, Christopher J</creatorcontrib><creatorcontrib>Wright, Ciaran R F</creatorcontrib><creatorcontrib>Lam, Sharon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current controlled trials in cardiovascular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashmi, Farina</au><au>Nester, Christopher J</au><au>Wright, Ciaran R F</au><au>Lam, Sharon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The evaluation of three treatments for plantar callus: a three-armed randomised, comparative trial using biophysical outcome measures</atitle><jtitle>Current controlled trials in cardiovascular medicine</jtitle><addtitle>Trials</addtitle><date>2016-05-17</date><risdate>2016</risdate><volume>17</volume><issue>1</issue><spage>251</spage><pages>251-</pages><artnum>251</artnum><issn>1745-6215</issn><eissn>1745-6215</eissn><abstract>Callus is one of the most common foot skin complaints experienced by people of all ages. These painful and unsightly lesions often result in disability. The 'gold standard' of treatment is scalpel debridement by a trained specialist; however, people also seek over-the-counter remedies. There is a lack of clinical evidence for the efficacy of such products, which makes selection by patients and practitioners difficult.
This randomised, three-armed, parallel, comparative trial aimed to test the efficacy of two home treatments for plantar callus using novel, objective outcome measures (skin hydration using the capacitance method; elasticity using negative pressure application; and surface texture using imaging). Additional outcome measures were: size of callus, quality of life (Foot Health Status Questionnaire) and self-reported participant satisfaction and compliance. The results were compared to a podiatry treatment. Participants were randomly allocated to one of three groups: potassium hydroxide (KOH, 40 %); trichloroacetic acid (TCA); and podiatry treatment. Participants were followed for 3 weeks after their initial intervention appointment (days 7, 14 and 21). The primary outcomes were the change from baseline in callus hydration, elasticity, texture, and size at each of the three time points. The secondary outcomes where: change in quality of life 21 days after treatment; resolution of calluses via visual inspection; and participant compliance and perception.
Forty-six participants (61 ft) with plantar calluses were recruited. The podiatry treatment showed immediate and significant changes in all objective outcomes, associated foot pain and function (p <0.01). Lesser changes in skin quality and perceived pain and functional benefits occurred with TCA and KOH over 21 days.
This is the first study where objective outcome measures have been used to measure changes in the nature of skin in response to callus treatments. We found significant differences in plantar callus in response to podiatry and two home treatments. The podiatry treatment showed immediate and significant changes in skin and associated foot pain and function. Lesser, but sometimes comparable, changes in skin and perceived pain and functional benefits occurred with TCA and KOH over 21 days.
ISRCTN14751843 : date of registration: 30 April 2015.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27189190</pmid><doi>10.1186/s13063-016-1377-2</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Current controlled trials in cardiovascular medicine, 2016-05, Vol.17 (1), p.251, Article 251 |
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| subjects | Administration, Cutaneous Adult Aged Analysis Callosities Callosities - diagnosis Callosities - physiopathology Callosities - therapy Care and treatment Caustics - administration & dosage Caustics - adverse effects Debridement Debridement - adverse effects Diabetes Diagnosis Elasticity England Female Foot diseases Foot Diseases - diagnosis Foot Diseases - physiopathology Foot Diseases - therapy Humans Hydration Hydroxides - administration & dosage Hydroxides - adverse effects Male Middle Aged Older people Pain Measurement Patient Compliance Patient Satisfaction Podiatry - methods Potash Potassium Potassium Compounds - administration & dosage Potassium Compounds - adverse effects Quality of Life Risk factors Skin Skin - metabolism Skin - pathology Skin - physiopathology Skin Physiological Phenomena Surveys and Questionnaires Time Factors Treatment Outcome Trichloroacetic Acid - administration & dosage Trichloroacetic Acid - adverse effects Water - metabolism Young Adult |
| title | The evaluation of three treatments for plantar callus: a three-armed randomised, comparative trial using biophysical outcome measures |
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