Memory deficit in patients with schizophrenia and posttraumatic stress disorder: relational vs item-specific memory

It has been well established that patients with schizophrenia have impairments in cognitive functioning and also that patients who experienced traumatic events suffer from cognitive deficits. Of the cognitive deficits revealed in schizophrenia or posttraumatic stress disorder (PTSD) patients, the cu...

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Bibliographic Details
Published in:Neuropsychiatric disease and treatment 2016-01, Vol.12, p.1157-1166
Main Authors: Jung, Wookyoung, Lee, Seung-Hwan
Format: Article
Language:English
Subjects:
Brain research
Care and treatment
Cognition & reasoning
Medical imaging
Memory
Mental disorders
Neurosciences
Post traumatic stress disorder
Psychiatry
Review
Schizophrenia
Semantics
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Summary:It has been well established that patients with schizophrenia have impairments in cognitive functioning and also that patients who experienced traumatic events suffer from cognitive deficits. Of the cognitive deficits revealed in schizophrenia or posttraumatic stress disorder (PTSD) patients, the current article provides a brief review of deficit in episodic memory, which is highly predictive of patients' quality of life and global functioning. In particular, we have focused on studies that compared relational and item-specific memory performance in schizophrenia and PTSD, because measures of relational and item-specific memory are considered the most promising constructs for immediate tangible development of clinical trial paradigm. The behavioral findings of schizophrenia are based on the tasks developed by the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative and the Cognitive Neuroscience Test Reliability and Clinical Applications for Schizophrenia (CNTRACS) Consortium. The findings we reviewed consistently showed that schizophrenia and PTSD are closely associated with more severe impairments in relational memory compared to item-specific memory. Candidate brain regions involved in relational memory impairment in schizophrenia and PTSD are also discussed.
ISSN:1176-6328
1178-2021
1178-2021
DOI:10.2147/NDT.S104384