Changes in mast cell infiltration: a possible mechanism in detrusor overactivity induced by visceral hypersensitivity

ABSTRACT Objective: To establish the detrusor overactivity (DO) model induced by visceral hypersensitivity (VH) and investigate the relationship between mast cell (MC) infiltration and DO. Materials and Methods: Sixty rats are divided into 4 groups randomly: Group 1:Baseline group; Group 2: DO group...

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Bibliographic Details
Published in:International Brazilian Journal of Urology 2016-03, Vol.42 (2), p.373-382
Main Authors: Zhang, Nian-zhao, Ma, Lin, Jun, Chen, Guo, Yan-xia, Yuan, Hui-qing
Format: Article
Language:English
Subjects:
Hypersensitivity
Mast-Cell Sarcoma
Original
Overactive
Urinary Bladder
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Summary:ABSTRACT Objective: To establish the detrusor overactivity (DO) model induced by visceral hypersensitivity (VH) and investigate the relationship between mast cell (MC) infiltration and DO. Materials and Methods: Sixty rats are divided into 4 groups randomly: Group 1:Baseline group; Group 2: DO group; Group 3: CON group; Group 4: VH group. The colorectal distension (CRD) and abdominal withdral reflex (AWR) scores are performed to evaluate VH. The cystometric investigation and histological test of MC infiltration are assessed. Results: The threshold pressure of CRD in the VH group is significantly lower than that in the CON group (P
ISSN:1677-5538
1677-6119
1677-5538
1677-6119
DOI:10.1590/S1677-5538.IBJU.2015.0025