The MyomiR network in skeletal muscle plasticity

MicroRNA (miRNA) are a class of noncoding RNA involved in regulating gene expression by a posttranscriptional mechanism. Based on work from our laboratory, this review explores the hypothesis that a recently described muscle-specific miRNA, myomiR, network has a central role in the regulation of ske...

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Bibliographic Details
Published in:Exercise and sport sciences reviews 2011-07, Vol.39 (3), p.150-154
Main Author: McCarthy, John J
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Animals
Gene Regulatory Networks
Humans
Mice
MicroRNAs - physiology
Muscle, Skeletal - physiology
Rats
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Summary:MicroRNA (miRNA) are a class of noncoding RNA involved in regulating gene expression by a posttranscriptional mechanism. Based on work from our laboratory, this review explores the hypothesis that a recently described muscle-specific miRNA, myomiR, network has a central role in the regulation of skeletal muscle plasticity by coordinating changes in fiber type and muscle mass in response to altered contractile activity.
ISSN:0091-6331
1538-3008
DOI:10.1097/jes.0b013e31821c01e1