Advanced imaging techniques in the therapeutic response of transarterial chemoembolization for hepatocellular carcinoma

Hepatocellular carcinoma(HCC) is one of the major causes of morbidity and mortality in patients with chronic liver disease. Transarterial chemoembolization(TACE) can significantly improve the survival rate of patients with HCC and is the first treatment choice for patients who are not suitable for s...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2016-05, Vol.22 (20), p.4835-4847
Main Authors: Yang, Ke, Zhang, Xiao-Ming, Yang, Lin, Xu, Hao, Peng, Juan
Format: Article
Language:English
Subjects:
Blood
Carcinoma, Hepatocellular - diagnostic imaging
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - therapy
Chemoembolization, Therapeutic
Diagnostic Imaging - methods
Humans
imaging
Chemoembolization
Diffusion
kurto
level-dependent
Computed
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - pathology
Liver Neoplasms - therapy
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Multimodal Imaging
oxygen
perfusion
Perfusion Imaging
Positron-Emission Tomography
Predictive Value of Tests
Reproducibility of Results
Review
tomography
Tomography, X-Ray Computed
Treatment Outcome
Tumor Burden
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Summary:Hepatocellular carcinoma(HCC) is one of the major causes of morbidity and mortality in patients with chronic liver disease. Transarterial chemoembolization(TACE) can significantly improve the survival rate of patients with HCC and is the first treatment choice for patients who are not suitable for surgical resections. The evaluation of the response to TACE treatment affects not only the assessment of the therapy efficacy but also the development of the next step in the treatment plan. The use of imaging to examine changes in tumor volume to assess the response of solid tumors to treatment has been controversial. In recent years, the emergence of new imaging technology has made it possible to observe the response of tumors to treatment prior to any morphological changes. In this article, the advances in studies reporting the use of computed tomography perfusion imaging, diffusionweighted magnetic resonance imaging(MRI), intravoxel incoherent motion, diffusion kurtosis imaging, magnetic resonance spectroscopy, magnetic resonance perfusionweighted imaging, blood oxygen level-dependent MRI, positron emission tomography(PET)/computed tomography and PET/MRI to assess the TACE treatment response are reviewed.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v22.i20.4835