The next-generation sequencing technology and application

As one of the key technologies in biomedical research, DNA sequencing has not only improved its productivity with an exponential growth rate but also been applied to new areas of application over the past few years. This is largely due to the advent of newer generations of sequencing platforms, offe...

Full description

Saved in:
Bibliographic Details
Published in:Protein & cell 2010-06, Vol.1 (6), p.520-536
Main Authors: Zhou, Xiaoguang, Ren, Lufeng, Meng, Qingshu, Li, Yuntao, Yu, Yude, Yu, Jun
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Cell Biology
Developmental Biology
DNA-Binding Proteins - chemistry
Epigenomics
Gene Expression Profiling
Genomics
High-Throughput Nucleotide Sequencing - instrumentation
High-Throughput Nucleotide Sequencing - methods
High-Throughput Nucleotide Sequencing - trends
Human Genetics
Humans
Life Sciences
Nanostructures
Protein Science
Review
RNA, Small Untranslated - chemistry
Stem Cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:As one of the key technologies in biomedical research, DNA sequencing has not only improved its productivity with an exponential growth rate but also been applied to new areas of application over the past few years. This is largely due to the advent of newer generations of sequencing platforms, offering ever-faster and cheaper ways to analyze sequences. In our previous review, we looked into technical characteristics of the next-generation sequencers and provided prospective insights into their future development. In this article, we present a brief overview of the advantages and shortcomings of key commercially available platforms with a focus on their suitability for a broad range of applications.
ISSN:1674-800X
1674-8018
DOI:10.1007/s13238-010-0065-3