Chinese herbal medicine Tangshen Formula treatment of patients with type 2 diabetic kidney disease with macroalbuminuria: study protocol for a randomized controlled trial

Diabetic kidney disease (DKD) is one of the most common microvascular complications of diabetes mellitus and the main cause of end-stage renal disease. Present medications for DKD are not entirely satisfactory. Preliminary studies indicate that the Chinese herbal formula Tangshen Formula (TSF) appea...

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Bibliographic Details
Published in:Current controlled trials in cardiovascular medicine 2016-05, Vol.17 (1), p.259-259, Article 259
Main Authors: Yan, Meihua, Wen, Yumin, Yang, Liping, Wu, Xi'ai, Lu, Xiaoguang, Zhang, Bingxuan, Huang, Weiping, Li, Ping
Format: Article
Language:English
Subjects:
Albuminuria - diagnosis
Albuminuria - drug therapy
Albuminuria - etiology
Biomarkers - blood
Blood pressure
Care and treatment
China
Chinese medicine
Clinical Protocols
Complications and side effects
Consent
Constipation
Creatinine
Creatinine - blood
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diagnosis
Diabetic Nephropathies - diagnosis
Diabetic Nephropathies - drug therapy
Diabetic Nephropathies - etiology
Diabetic retinopathy
Double-Blind Method
Drugs, Chinese Herbal - adverse effects
Drugs, Chinese Herbal - therapeutic use
Edema
Glomerular Filtration Rate - drug effects
Health aspects
Hematuria
Hospitals
Humans
Hypertension
Kidney - drug effects
Kidney - physiopathology
Kidney diseases
Medicinal plants
Medicine, Chinese
Methods
Patient outcomes
Research Design
Study Protocol
Time Factors
Treatment Outcome
Urination
Womens health
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Summary:Diabetic kidney disease (DKD) is one of the most common microvascular complications of diabetes mellitus and the main cause of end-stage renal disease. Present medications for DKD are not entirely satisfactory. Preliminary studies indicate that the Chinese herbal formula Tangshen Formula (TSF) appears to decrease the proteinuria and improve the estimated glomerular filtration rate (eGFR) in DKD patients. This trial is a five-center, randomized, double-blind, placebo-controlled study. DKD patients with a 24-h urinary protein (24 h UP) level between 0.5 and 3.5 g and serum creatinine 
ISSN:1745-6215
1745-6215
DOI:10.1186/s13063-016-1385-2