Rates of and Risk Factors for Trabecular and Cortical BMD Loss in Middle‐Aged and Elderly African‐Ancestry Men

ABSTRACT Low trabecular (Tb) and cortical (Ct) volumetric BMD (vBMD) are related to increased fracture risk, but little is known about the patterns and correlates of Tb and Ct vBMD loss with aging. We examined the rates of change in total, Tb.vBMD, and Ct.vBMD at the radius and tibia, and identified...

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Bibliographic Details
Published in:Journal of bone and mineral research 2015-03, Vol.30 (3), p.543-553
Main Authors: Sheu, Yahtyng, Bunker, Clareann H, Jonnalagadda, Pallavi, Cvejkus, Ryan K, Patrick, Alan L, Wheeler, Victor W, Gordon, Christopher L, Zmuda, Joseph M
Format: Article
Language:English
Subjects:
African Americans
AFRICAN‐ANCESTRY MEN
Aged
AGING
Bone Density
Humans
Male
Middle Aged
OSTEOPOROSIS
Osteoporosis - epidemiology
PERIPHERAL QCT
Risk Factors
Tomography, X-Ray Computed
TRABECULAR AND CORTICAL BMD
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Summary:ABSTRACT Low trabecular (Tb) and cortical (Ct) volumetric BMD (vBMD) are related to increased fracture risk, but little is known about the patterns and correlates of Tb and Ct vBMD loss with aging. We examined the rates of change in total, Tb.vBMD, and Ct.vBMD at the radius and tibia, and identified factors associated with vBMD loss among 1569 men of African descent aged 40 years and older. Quantitative computed tomography was used to measure vBMD 6 years apart. The annualized rate of loss in Tb.vBMD was significant at the radius (–0.047%/yr, p = 0.016) but not at the tibia. At the radius, a significant loss of Tb.vBMD was observed in men aged 40 to 49 years that appeared to be attenuated and not statistically significant among older age men. In contrast, the decline in Ct.vBMD was similar at both skeletal sites (–0.254 to –0.264%/yr, p 
ISSN:0884-0431
1523-4681
DOI:10.1002/jbmr.2359