Effects of fixed or self-titrated dosages of Sativex on cannabis withdrawal and cravings

Highlights • There is currently no pharmacological treatment approved for cannabis dependence. • The effect of the combination of THC/CBD on cannabis withdrawal and cravings was studied. • High doses of Sativex were well tolerated and reduced cannabis withdrawal. • These data constitute support for...

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Bibliographic Details
Published in:Drug and alcohol dependence 2016-04, Vol.161, p.298-306
Main Authors: Trigo, Jose M, Lagzdins, Dina, Rehm, Jürgen, Selby, Peter, Gamaleddin, Islam, Fischer, Benedikt, Barnes, Allan J, Huestis, Marilyn A, Le Foll, Bernard
Format: Article
Language:English
Subjects:
Adult
Cannabidiol
Cannabis
Cannabis - adverse effects
Clinical trials.gov ID# NCT01748799
Craving - drug effects
Double-Blind Method
Dronabinol
Drug Combinations
Female
Humans
Male
Marijuana
Marijuana Abuse - drug therapy
Marijuana Smoking
Middle Aged
Plant Extracts - administration & dosage
Plant Extracts - therapeutic use
Psychiatry
Substance Withdrawal Syndrome - drug therapy
Substance-Related Disorders - drug therapy
THC
Treatment Outcome
Withdrawal
Young Adult
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Summary:Highlights • There is currently no pharmacological treatment approved for cannabis dependence. • The effect of the combination of THC/CBD on cannabis withdrawal and cravings was studied. • High doses of Sativex were well tolerated and reduced cannabis withdrawal. • These data constitute support for use of Sativex to attenuate cannabis withdrawal.
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2016.02.020