Outcome and Prognostic Factors After Adrenalectomy for Patients with Distant Adrenal Metastasis

Background The purpose of this study was to describe a single-institution experience with adrenal metastasectomy and to elucidate factors that may bear prognostic significance. Methods This is a single-center, retrospective review of patients with adrenal metastasis who underwent adrenalectomy perfo...

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Bibliographic Details
Published in:Annals of surgical oncology 2013-10, Vol.20 (11), p.3491-3496
Main Authors: Howell, Gina M., Carty, Sally E., Armstrong, Michaele J., Stang, Michael T., McCoy, Kelly L., Bartlett, David L., Yip, Linwah
Format: Article
Language:English
Subjects:
Adrenal Gland Neoplasms - mortality
Adrenal Gland Neoplasms - secondary
Adrenal Gland Neoplasms - surgery
Adrenalectomy - mortality
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - surgery
Endocrine Tumors
Female
Follow-Up Studies
Humans
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Male
Medicine
Medicine & Public Health
Metastasectomy - mortality
Middle Aged
Neoplasm Staging
Oncology
Prognosis
Retrospective Studies
Surgery
Surgical Oncology
Survival Rate
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Summary:Background The purpose of this study was to describe a single-institution experience with adrenal metastasectomy and to elucidate factors that may bear prognostic significance. Methods This is a single-center, retrospective review of patients with adrenal metastasis who underwent adrenalectomy performed with curative intent between 2000 and 2012. The Kaplan–Meier method was used to evaluate overall survival from time of adrenalectomy to death or last follow-up. Primary endpoint was death from any cause. Clinical variables were examined for association with survival. Results The study included 62 patients with mean age of 60 (±12) years; 55 % (34 of 62) were male, 85 % (53 of 62) presented with isolated adrenal metastasis, and 82 % (51 of 62) had metachronous disease with median disease-free interval (DFI) of 22 months (range, 6–217 months). Non-small cell lung cancer (NSCLC) was the most common primary comprising 50 % of cases. Median survival for the study population was 30 months (range, 1–145 months) and 5-year survival was 31 %. Patients with NSCLC had significantly shortened survival compared with non-NSCLC with median and 5-year survival of 17 versus 47 months and 27 % versus 38 %, respectively ( p  = .033). Synchronous metastasis ( p  = .028) and DFI 
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-013-3050-2