Tissue‐resident mesenchymal stem/progenitor cells in skeletal muscle: collaborators or saboteurs?

Although the regenerative potential of adult skeletal muscle is maintained by satellite cells, other stem/progenitor cell populations also reside in skeletal muscle. These heterogeneous cellular pools with mesenchymal lineage potentially play important roles in tissue homeostasis, with reciprocal co...

Full description

Saved in:
Bibliographic Details
Published in:The FEBS journal 2013-09, Vol.280 (17), p.4100-4108
Main Authors: Judson, Robert N., Zhang, Regan‐Heng, Rossi, Fabio M. A.
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Cellular biology
fibro/adipogentic progenitors
Humans
mesenchymal stem cells
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - physiology
Muscle Development - physiology
muscular dystrophy
Musculoskeletal system
myogenesis
Regeneration - physiology
regenerative medicine
satellite cells
Satellite Cells, Skeletal Muscle - cytology
Satellite Cells, Skeletal Muscle - physiology
skeletal muscle
Stem cells
tissue regeneration
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although the regenerative potential of adult skeletal muscle is maintained by satellite cells, other stem/progenitor cell populations also reside in skeletal muscle. These heterogeneous cellular pools with mesenchymal lineage potentially play important roles in tissue homeostasis, with reciprocal collaborations between these cells and satellite cells appearing critical for effective regeneration. However, in disease settings, these mesenchymal stem/progenitors adopt a more sinister role – likely providing a major source of fibrosis, fatty tissue and extracellular matrix protein deposition in dystrophic tissue. Development of therapies for muscle degeneration therefore requires complete understanding of the multiple cell types involved and their complex interactions. Like most postnatal tissues, skeletal muscle plays host to a heterogeneous pool of tissue resident mesenchymal stem/progenitor cells. These progenitors play critical supporting roles in regeneration, collaborating with the host stem cell pool (satellite cells) to ensure effective repair. In disease, however, mesenchymal stem/progenitor cells adopt a more sinister role, sabotaging regeneration and providing a major source of fibrosis in dystrophic muscle.
ISSN:1742-464X
1742-4658
DOI:10.1111/febs.12370