GC-MS Analysis: In Vivo Hepatoprotective and Antioxidant Activities of the Essential Oil of Achillea biebersteinii Afan. Growing in Saudi Arabia

Liver disease is a worldwide problem. It represents one of the main causes of morbidity and mortality in humans. Achillea biebersteinii is used as herbal remedy for various ailments including liver diseases. But the scientific basis for its medicinal use remains unknown. Thus, this research was unde...

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Published in:Evidence-based complementary and alternative medicine 2016-01, Vol.2016 (2016), p.1-8
Main Authors: Baser, Husnu C., Kurkcuoglu, Mine, Alatar, Abdulrahman, Khaled, Jamal M., Al-Sohaibani, Mohammed, Rafatullah, Syed, al-Yahya, Mohammed, Mothana, R. A. A., al-Said, Mansour, al-Harbi, Naif O.
Format: Article
Language:English
Subjects:
Academic libraries
Achillea
Albinism
Analysis
Antioxidants
Beta carotene
Bilirubin
Chromatography
Drug dosages
Enzymes
Ethylenediaminetetraacetic acid
Health aspects
Hepatitis
Lipid peroxidation
Lipids
Liver
Liver diseases
Medicine, Botanic
Medicine, Herbal
Mortality
Oils & fats
Oxidative stress
Pharmaceutical sciences
Pharmacy
Phosphatases
Retention
Rodents
Studies
Unsaturated fatty acids
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Summary:Liver disease is a worldwide problem. It represents one of the main causes of morbidity and mortality in humans. Achillea biebersteinii is used as herbal remedy for various ailments including liver diseases. But the scientific basis for its medicinal use remains unknown. Thus, this research was undertaken to evaluate the efficiency of A. biebersteinii essential oil (ABEO) (0.2 mL/kg) in the amelioration of CCl4-induced hepatotoxicity in rodent model. Moreover, the chemical content of the oil was investigated using GC and GC-MS. The following biochemical parameters were evaluated: serum glutamic oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), gamma-glutamyl-transpeptidase (γ-GGT), alkaline phosphatase (ALP), and total bilirubin. Furthermore, lipid profile, malondialdehyde (MDA), nonprotein sulfhydryl (NP-SH), and total protein (TP) contents in liver tissue were estimated. 44 components (92.0%) of the total oil have been identified by GC-MS analysis where α-terpinene and p -cymene were the most abundant. The high serum enzymatic (GOT, GPT, GGT, and ALP) and bilirubin concentrations as well as the level of MDA, NP-SH, and TP contents in liver tissues were significantly reinstated towards normalization by the ABEO. Histopathological study further confirmed these findings. In addition, ABEO showed mild antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and β-carotene-linoleic acid assays.
ISSN:1741-427X
1741-4288
DOI:10.1155/2016/1867048