The Role of Catalase C262T Gene Polymorphism in the Susceptibility and Survival of Cancers

Catalase (CAT), one antioxidant enzyme, may provide resistance against many diseases. Many previous studies reported predictive and prognostic values of CAT C262T polymorphism in cancers, with divergent results. This study aimed to summarize the overall relationships between CAT C262T polymorphism a...

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Bibliographic Details
Published in:Scientific reports 2016-05, Vol.6 (1), p.26973-26973, Article 26973
Main Authors: Wang, Cheng-Di, Sun, Yan, Chen, Nan, Huang, Lin, Huang, Jing-Wen, Zhu, Min, Wang, Ting, Ji, Yu-Lin
Format: Article
Language:English
Subjects:
631/208/68
631/337/1427
631/67/69
Cancer
Catalase
Gene polymorphism
Health risk assessment
Health risks
Humanities and Social Sciences
multidisciplinary
Prostate cancer
Science
Science (multidisciplinary)
Survival
Survival analysis
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Summary:Catalase (CAT), one antioxidant enzyme, may provide resistance against many diseases. Many previous studies reported predictive and prognostic values of CAT C262T polymorphism in cancers, with divergent results. This study aimed to summarize the overall relationships between CAT C262T polymorphism and cancer risk or survival. A total of 27 eligible publications were included in susceptibility analysis, while 8 publications contained survival outcomes. The results revealed significant relationship between CAT C262T polymorphism and cancer risk(TT + CT vs CC: OR = 1.05, 95%CI = 1.00–1.10, P = 0.036), subgroup analyses indicated the CAT C262T polymorphism was significantly correlated with an increased risk for prostate cancer (TT vs CC + CT: OR = 1.43, 95%CI = 1.20–1.70, P 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep26973